Increased nucleus accumbens volume in first-episode psychosis

Mireia Forns-Nadal, Daniel Bergé, Federico Sem, Anna Mané, Laura Igual, Dani Guinart, Oscar Vilarroya

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)


© 2017 Elsevier Ireland Ltd Nucleus accumbens has been reported as a key structure in the neurobiology of schizophrenia. Studies analyzing structural abnormalities have shown conflicting results, possibly related to confounding factors. We investigated the nucleus accumbens volume using manual delimitation in first-episode psychosis (FEP) controlling for age, cannabis use and medication. Thirty-one FEP subjects who were naive or minimally exposed to antipsychotics and a control group were MRI scanned and clinically assessed from baseline to 6 months of follow-up. FEP showed increased relative and total accumbens volumes. Clinical correlations with negative symptoms, duration of untreated psychosis and cannabis use were not significant.
Original languageEnglish
Pages (from-to)57-60
JournalPsychiatry Research - Neuroimaging
Publication statusPublished - 30 May 2017


  • Neuroimaging
  • Region of interest
  • Reward
  • Schizophrenia


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