Increased incidence of disomic sperm nuclei in a 47,XYY male assessed by fluorescent in situ hybridization (FISH)

Joan Blanco, Carmen Rubio, Carlos Simon, Josep Egozcue, Francesca Vidal

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74 Citations (Scopus)

Abstract

Using triple-colour fluorescent in situ hybridization in decondensed sperm heads, we assessed the sex-chromosome distribution in spermatozoa from a 47,XYY male compared with controls. The incidence of spermatozoa with 24,XY (0.30%) and 24,YY (1.01%) disomy was significantly higher than in our control series. Diploid meiocytes present in the ejaculate were mainly 47,XYY (60.6-86.7%), and haploid meiocytes were mainly 24,XY (78.1%). These results suggest that, although the extra Y chromosome is thought to be eliminated during spermatogenesis, XYY germ cells can complete meiosis and produce disomic spermatozoa.
Original languageEnglish
Pages (from-to)413-416
JournalHuman Genetics
Volume99
DOIs
Publication statusPublished - 1 Mar 1997

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