TY - JOUR
T1 - Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis
AU - Comabella, Manuel
AU - Hegen, Harald
AU - Villar, Luisa M
AU - Rejdak, Konrad
AU - Sao-Avilés, Augusto
AU - Behrens, Malina
AU - Sastre-Garriga, Jaume
AU - Mongay, Neus
AU - Berek, Klaus
AU - Martínez-Yelamos, Sergio
AU - Pérez-Miralles, Francisco
AU - Abdelhak, Ahmed
AU - Bachhuber, Franziska
AU - Tumani, Hayrettin
AU - Lycke, Jan
AU - Carbonell-Mirabent, Pere
AU - Valls-Carbó, Adrián
AU - Rosenstein, Igal
AU - Alvarez-Lafuente, Roberto
AU - Castillo-Triviño, Tamara
AU - Otaegui, David
AU - Llufriu, Sara
AU - Blanco, Yolanda
AU - Sánchez-López, Antonio J
AU - García-Merino, Antonio
AU - Fissolo, Nicolás
AU - Gutiérrez, Lucía
AU - Villacieros-Álvarez, Javier
AU - Monreal, Enric
AU - Wiendl, Heinz
AU - Montalban, Xavier
AU - Lünemann, Jan D
N1 - © 2024. The Author(s).
PY - 2024/12/12
Y1 - 2024/12/12
N2 - BACKGROUND AND OBJECTIVES: The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).METHODS: Antibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.RESULTS: Compared with controls, PPMS patients showed increased humoral immune responses to the EBV-encoded nuclear antigen-1 (EBNA1), but not to the lytic EBV capsid antigen (VCA) or to other viral antigens. Seroprevalence rates for HCMV were significantly higher in PPMS. Antiviral immune responses at baseline did not correlate with disability progression over time.DISCUSSION: Elevated immune responses toward EBNA1 are selectively increased in people with primary progressive disease, indicating a link between EBNA1-targeting immune responses and the development of both RMS and PPMS. Our data also suggest that chronic HCMV infection is associated with progressive MS.
AB - BACKGROUND AND OBJECTIVES: The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).METHODS: Antibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.RESULTS: Compared with controls, PPMS patients showed increased humoral immune responses to the EBV-encoded nuclear antigen-1 (EBNA1), but not to the lytic EBV capsid antigen (VCA) or to other viral antigens. Seroprevalence rates for HCMV were significantly higher in PPMS. Antiviral immune responses at baseline did not correlate with disability progression over time.DISCUSSION: Elevated immune responses toward EBNA1 are selectively increased in people with primary progressive disease, indicating a link between EBNA1-targeting immune responses and the development of both RMS and PPMS. Our data also suggest that chronic HCMV infection is associated with progressive MS.
KW - Epstein-Barr virus
KW - Human cytomegalovirus
KW - Multiple sclerosis
KW - Primary progressive
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=85211895667&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/916345eb-0707-3ef2-ab07-3eb023e3dccd/
U2 - 10.1007/s00415-024-12763-w
DO - 10.1007/s00415-024-12763-w
M3 - Article
C2 - 39666032
SN - 0340-5354
VL - 272
JO - Journal of Neurology
JF - Journal of Neurology
IS - 1
M1 - 26
ER -
