Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis

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33 Citations (Scopus)

Abstract

Metallothioneins I+II (MT-I+II) are antioxidant, neuroprotective factors. We previously showed that MT-I+II deficiency during experimental autoimmune encephalomyelitis (EAE) leads to increased disease incidence and clinical symptoms. Moreover, the inflammatory response of macrophages and T cells, oxidative stress, and apoptotic cell death during EAE were increased by MT-I+II deficiency. We now show for the first time that demyelination and axonal damage are significantly increased in MT-I+II deficient mice during EAE. Furthermore, oligodendroglial regeneration, growth cone formation, and tissue repair including expression of trophic factors were significantly reduced in MT-I+II-deficient mice during EAE. Accordingly, MT-I+II have protective and regenerative roles in the brain.
Original languageEnglish
Pages (from-to)185-197
JournalCellular and Molecular Life Sciences
Volume60
DOIs
Publication statusPublished - 1 Jan 2003

Keywords

  • Demyelination
  • EAE/MS
  • Metallothionein
  • Neurodegeneration
  • Neurotrophic factor
  • Regeneration

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