Increase of secondary processes of microglial and astroglial cells after MPTP-Induced degeneration in substantia nigra pars compacta of non human primates

Carlos Barcia*, Carmen M. Ros, María A. Carrillo, Francisco Ros, Aurora Gomez, Vicente De Pablos, Victor Bautista-Hernández, Angel Sánchez-Bahillo, Emiliano Fernández Villalba, Maria Trinidad Herrero

*Corresponding author for this work

Research output: Chapter in BookChapterResearchpeer-review

8 Citations (Scopus)

Abstract

Nigral dopaminergic areas from Parkinsonian patients show an increase of reactive astrocytes and active microglia. The reaction of these two cell types is a clear evidence of inflammatory response associated with dopaminergic cell loss. However, the function of this glial reaction remains unclear. This histological hallmark is also reproduced in induced Parkinsonian animals such as MPTP-treated monkeys. In this work, we analyze with confocal microscopy the number of processes of microglial cells and astrocytes in the SNpc of MPTP-treated monkeys and compare with control animals. We observe that secondary branches from microglia and astrocytes increase in MPTP-treated animals, while the scaffold of primary branches does not change. These results demonstrate that glial reaction in MPTP-treated monkeys is characterized by the emission of new filaments after the dopaminergic degeneration, suggesting that glial cells may increase their scanning progress and modify their microanatomy after dopaminergic injury.

Original languageEnglish
Title of host publicationBirth, Life and Death of Dopaminergic Neurons in the Substantia Nigra
PublisherSpringer-Verlag Wien
Pages253-258
Number of pages6
Edition73
ISBN (Print)9783211926598
DOIs
Publication statusPublished - 2009

Publication series

NameJournal of Neural Transmission, Supplementa
Number73
ISSN (Print)0303-6995

Keywords

  • Astroglia
  • Glial reaction
  • Microglia
  • Neuroinflammation
  • Parkinson's disease

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