Increase in quinolone resistance in a Haemophilus influenzae strain isolated from a patient with recurrent respiratory infections treated with ofloxacin

Jordi Vila, Joaquim Ruiz, Ferran Sanchez, Ferran Navarro, Beatriz Mirelis, M. Teresa Jimenez De Anta, Guillem Prats

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Abstract

The increase in the level of quinolone resistance of Haemophilus influenzae clinical isolates during ofloxacin therapy of a patient with recurrent respiratory infections was investigated. The first isolate (MIC of ciprofloxacin of 2 μg/ml) and the second isolate (MIC of 32 μg/ml) belonged to the same clone, as shown by pulsed-field gel electrophoresis, and the increase in the resistance level was associated with a substitution in Ser- 84 to Arg in the Parc protein. These results emphasize the potential risk of development of quinolone-resistant H. influenzae during fluoroquinolone therapy in patients with recurrent respiratory infection.
Original languageEnglish
Pages (from-to)161-162
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number1
Publication statusPublished - 15 Feb 1999

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    Vila, J., Ruiz, J., Sanchez, F., Navarro, F., Mirelis, B., Jimenez De Anta, M. T., & Prats, G. (1999). Increase in quinolone resistance in a Haemophilus influenzae strain isolated from a patient with recurrent respiratory infections treated with ofloxacin. Antimicrobial Agents and Chemotherapy, 43(1), 161-162.