The increase in the level of quinolone resistance of Haemophilus influenzae clinical isolates during ofloxacin therapy of a patient with recurrent respiratory infections was investigated. The first isolate (MIC of ciprofloxacin of 2 μg/ml) and the second isolate (MIC of 32 μg/ml) belonged to the same clone, as shown by pulsed-field gel electrophoresis, and the increase in the resistance level was associated with a substitution in Ser- 84 to Arg in the Parc protein. These results emphasize the potential risk of development of quinolone-resistant H. influenzae during fluoroquinolone therapy in patients with recurrent respiratory infection.
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - 15 Feb 1999|
Vila, J., Ruiz, J., Sanchez, F., Navarro, F., Mirelis, B., Jimenez De Anta, M. T., & Prats, G. (1999). Increase in quinolone resistance in a Haemophilus influenzae strain isolated from a patient with recurrent respiratory infections treated with ofloxacin. Antimicrobial Agents and Chemotherapy, 43(1), 161-162.