Incorporating BIRD-based homodecoupling in the dual-optimized, inverted <sup>1</sup>J<inf>CC</inf> 1,n-ADEQUATE experiment

Josep Saurí, Wolfgang Bermel, Teodor Parella, R. Thomas Williamson, Gary E. Martin

    Research output: Contribution to journalArticleResearch

    3 Citations (Scopus)

    Abstract

    Copyright © 2018 John Wiley & Sons, Ltd. 1,n-ADEQUATE is a powerful NMR technique for elucidating the structure of proton-deficient small molecules that can help establish the carbon skeleton of a given molecule by providing long-range three-bond 13C─13C correlations. Care must be taken when using the experiment to identify the simultaneous presence of one-bond 13C─13C correlations that are not filtered out, unlike the HMBC experiment that has a low-pass J-filter to filter 1JCH responses out. Dual-optimized, inverted 1JCC 1,n-ADEQUATE is an improved variant of the experiment that affords broadband inversion of direct responses, obviating the need to take additional steps to identify these correlations. Even though ADEQUATE experiments can now be acquired in a reasonable amount of experimental time if a cryogenic probe is available, low sensitivity is still the main impediment limiting the application of this elegant experiment. Here, we wish to report a further refinement that incorporates real-time bilinear rotation decoupling-based homodecoupling methodology into the dual-optimized, inverted 1JCC 1,n-ADEQUATE pulse sequence. Improved sensitivity and resolution are achieved by collapsing homonuclear proton–proton couplings from the observed multiplets for most spin systems. The application of the method is illustrated with several model compounds.
    Original languageEnglish
    Pages (from-to)1029-1036
    JournalMagnetic Resonance in Chemistry
    Volume56
    DOIs
    Publication statusPublished - 1 Oct 2018

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