Incidence of trisomy 8 and 9, deletion of D13s319 and 020S108 loci and BCR/ABL translocation in non-treated essential thrombocythemia patients: An analysis of bone marrow cells using interphase fluorescence in situ hybridization

Lurdes Zamora, Blanca Espinet, Lourdes Florensa, Carles Besses, Marta Salido, Francesc Sole

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Abstract

We compare conventional cytogenetics (CC) with fluorescence in situ hybridization (FISH) in 53 untreated patients with essential thrombocythemia. CC revealed no abnormalities. When FISH was used, no BCR/ABL rearrangement nor trisomy 8 was found, but one trisomy 9, two del(13)(q14) and five del(20)(q12) were observed. FISH detected chromosome abnormalities in 15% of patients in which no alteration was found by CC.
Original languageEnglish
Pages (from-to)110-111
JournalHaematologica
Volume88
Issue number1
Publication statusPublished - 1 Feb 2003

Keywords

  • Conventional cytogenetics
  • Essential thrombocythemia
  • FISH

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