Incidence of trisomy 8 and 9, deletion of D13s319 and 020S108 loci and BCR/ABL translocation in non-treated essential thrombocythemia patients: An analysis of bone marrow cells using interphase fluorescence in situ hybridization

Lurdes Zamora; Blanca Espinet; Lourdes Florensa; Carles Besses; Marta Salido; Francesc Sole

Incidence of trisomy 8 and 9, deletion of D13s319 and 020S108 loci and BCR/ABL translocation in non-treated essential thrombocythemia patients: An analysis of bone marrow cells using interphase fluorescence in situ hybridization

Lurdes Zamora, Blanca Espinet, Lourdes Florensa, Carles Besses, Marta Salido, Francesc Sole

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

We compare conventional cytogenetics (CC) with fluorescence in situ hybridization (FISH) in 53 untreated patients with essential thrombocythemia. CC revealed no abnormalities. When FISH was used, no BCR/ABL rearrangement nor trisomy 8 was found, but one trisomy 9, two del(13)(q14) and five del(20)(q12) were observed. FISH detected chromosome abnormalities in 15% of patients in which no alteration was found by CC.

Original language	English
Pages (from-to)	110-111
Journal	Haematologica
Volume	88
Issue number	1
Publication status	Published - 1 Feb 2003

Keywords

Conventional cytogenetics
Essential thrombocythemia
FISH

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Zamora, Lurdes ; Espinet, Blanca ; Florensa, Lourdes ; Besses, Carles ; Salido, Marta ; Sole, Francesc. / Incidence of trisomy 8 and 9, deletion of D13s319 and 020S108 loci and BCR/ABL translocation in non-treated essential thrombocythemia patients: An analysis of bone marrow cells using interphase fluorescence in situ hybridization. In: Haematologica. 2003 ; Vol. 88, No. 1. pp. 110-111.

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abstract = "We compare conventional cytogenetics (CC) with fluorescence in situ hybridization (FISH) in 53 untreated patients with essential thrombocythemia. CC revealed no abnormalities. When FISH was used, no BCR/ABL rearrangement nor trisomy 8 was found, but one trisomy 9, two del(13)(q14) and five del(20)(q12) were observed. FISH detected chromosome abnormalities in 15% of patients in which no alteration was found by CC.",

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Incidence of trisomy 8 and 9, deletion of D13s319 and 020S108 loci and BCR/ABL translocation in non-treated essential thrombocythemia patients: An analysis of bone marrow cells using interphase fluorescence in situ hybridization. / Zamora, Lurdes; Espinet, Blanca; Florensa, Lourdes; Besses, Carles; Salido, Marta; Sole, Francesc.

In: Haematologica, Vol. 88, No. 1, 01.02.2003, p. 110-111.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Incidence of trisomy 8 and 9, deletion of D13s319 and 020S108 loci and BCR/ABL translocation in non-treated essential thrombocythemia patients: An analysis of bone marrow cells using interphase fluorescence in situ hybridization

AU - Zamora, Lurdes

AU - Espinet, Blanca

AU - Florensa, Lourdes

AU - Besses, Carles

AU - Salido, Marta

AU - Sole, Francesc

PY - 2003/2/1

Y1 - 2003/2/1

N2 - We compare conventional cytogenetics (CC) with fluorescence in situ hybridization (FISH) in 53 untreated patients with essential thrombocythemia. CC revealed no abnormalities. When FISH was used, no BCR/ABL rearrangement nor trisomy 8 was found, but one trisomy 9, two del(13)(q14) and five del(20)(q12) were observed. FISH detected chromosome abnormalities in 15% of patients in which no alteration was found by CC.

AB - We compare conventional cytogenetics (CC) with fluorescence in situ hybridization (FISH) in 53 untreated patients with essential thrombocythemia. CC revealed no abnormalities. When FISH was used, no BCR/ABL rearrangement nor trisomy 8 was found, but one trisomy 9, two del(13)(q14) and five del(20)(q12) were observed. FISH detected chromosome abnormalities in 15% of patients in which no alteration was found by CC.

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KW - Essential thrombocythemia

KW - FISH

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