Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization

J. Blanco, J. Egozcue, F. Vidal

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Abstract

We have evaluated the incidence of chromosome 21 disomy in decondensed sperm heads from nine normal men using a locus-specific DNA probe for chromosome 21, and a centromeric probe for chromosome 6 as a control. The results show that the incidence of chromosome 21 disomy (0.38%) is significantly higher than disomy for chromosome 6 (0.14%). No differences were found among the individuals analysed.
Original languageEnglish
Pages (from-to)722-726
JournalHuman Reproduction
Volume11
Issue number4
DOIs
Publication statusPublished - 1 Jan 1996

Keywords

  • Chromosome 21
  • Disomy
  • Spermatozoa

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