Inactivation of hepatitis B virus: Evaluation of the efficacy of the disinfectant 'Solprogel' using a DNA-polymerase activity assay

A. Hernández, F. J. Belda, J. Domínguez, L. Matas, M. Giménez, M. Caraballo, C. Ramil, V. Ausina

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10 Citations (Scopus)

Abstract

The effects of sodium dichloroisocyanurate (NaDCC) and Solprogel (Laboratories Inibsa, S.A., Barcelona, Spain), a compound that contains NaDCC plus a biodegradable polymer of acrylic acid, on the activity of DNA polymerase (DNA-P) associated with hepatitis B virus in serum were evaluated. DNA-P positive and negative pools of human serum samples were used as positive and negative stock virus. Inhibition of DNA-P activity by NaDCC and the commercial product was found to be concentration-dependent. Two minutes exposure to the minimum effective concentration of NaDCC (1000 ppm available chlorine) or Solprogel 16% (960 ppm available chlorine) totally inhibited DNA-P activity.
Original languageEnglish
Pages (from-to)305-312
JournalJournal of Hospital Infection
Volume36
Issue number4
DOIs
Publication statusPublished - 1 Jan 1997

Keywords

  • DNA-polymerase
  • Hepatitis B virus
  • Sodium dichloroisocyanurate
  • Solprogel

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