Inactivation of basal glycogen synthase by glucagon and epinephrine in hepatocytes from fed rats

Fàtima Bosch, Carles J. Ciudad, Joan J. Guinovart

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Glucagon and epinephrine promote the inactivation of basal glycogen synthase in hepatocytes isolated from fed rats. However, this effect is only observable when the activation state of glycogen synthase is measured using the low glucose-6-P/high glucose-6-P activity ratio assay. This inactivation is the consequence of an increase in the kinetic parameters (S0.5 for UDP-glucose and M0.5 for glucose-6-P) of the enzyme. Therefore, this work demonstrates these hormones are also able to control glycogen synthase from fed animals. © 1986.
Original languageEnglish
Pages (from-to)47-50
JournalFEBS Letters
Volume200
Issue number1
DOIs
Publication statusPublished - 5 May 1986

Keywords

  • (Rat hepatocyte) Glucagon Epinephrine Glycogen synthase

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