Inactivation of basal glycogen synthase by glucagon and epinephrine in hepatocytes from fed rats

Fàtima Bosch; Carles J. Ciudad; Joan J. Guinovart

doi:10.1016/0014-5793(86)80508-7

Inactivation of basal glycogen synthase by glucagon and epinephrine in hepatocytes from fed rats

Fàtima Bosch, Carles J. Ciudad, Joan J. Guinovart

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

Glucagon and epinephrine promote the inactivation of basal glycogen synthase in hepatocytes isolated from fed rats. However, this effect is only observable when the activation state of glycogen synthase is measured using the low glucose-6-P/high glucose-6-P activity ratio assay. This inactivation is the consequence of an increase in the kinetic parameters (S0.5 for UDP-glucose and M0.5 for glucose-6-P) of the enzyme. Therefore, this work demonstrates these hormones are also able to control glycogen synthase from fed animals. © 1986.

Original language	English
Pages (from-to)	47-50
Journal	FEBS Letters
Volume	200
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(86)80508-7
Publication status	Published - 5 May 1986

Keywords

(Rat hepatocyte) Glucagon Epinephrine Glycogen synthase

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abstract = "Glucagon and epinephrine promote the inactivation of basal glycogen synthase in hepatocytes isolated from fed rats. However, this effect is only observable when the activation state of glycogen synthase is measured using the low glucose-6-P/high glucose-6-P activity ratio assay. This inactivation is the consequence of an increase in the kinetic parameters (S0.5 for UDP-glucose and M0.5 for glucose-6-P) of the enzyme. Therefore, this work demonstrates these hormones are also able to control glycogen synthase from fed animals. {\textcopyright} 1986.",

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