Inactivated PCV2 one shot vaccine applied in 3-week-old piglets: Improvement of production parameters and interaction with maternally derived immunity

Lorenzo Fraile, Llorenç Grau-Roma, Patxi Sarasola, Nuria Sinovas, Miquel Nofrarías, Rosa López-Jimenez, Sergio López-Soria, Marina Sibila, Joaquim Segalés

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51 Citations (Scopus)

Abstract

The present study describes the effects of a commercially available vaccine against Porcine circovirus type 2 (PCV2) on clinical, pathological and virological outcomes of 3-week-old piglets from two farms with a clinical history of postweaning multisystemic wasting syndrome (PMWS). The study was a controlled, double-blinded, parallel group (1:1) and randomized trial (with a negative control) involving a total of 1239 animals. The study period comprised from weaning age (time of vaccination or PBS inoculation) until the first shipment of pigs to the slaughterhouse. The vaccine product was able to reduce clinical signs, PCV2 viral load in sera and faeces, and overall mortality in nurseries and fattening units. Moreover, average daily gain was significantly higher in vaccinated versus non-vaccinated piglets during the trial period. On the other hand, it was shown that maternally derived antibodies interfered with the development of an active humoral immune response after PCV2 vaccination. © 2012 Elsevier Ltd.
Original languageEnglish
Pages (from-to)1986-1992
JournalVaccine
Volume30
Issue number11
DOIs
Publication statusPublished - 2 Mar 2012

Keywords

  • Inactivated vaccine
  • Maternal immunity interference
  • Porcine circovirus type 2 (PCV2)
  • Postweaning multisystemic wasting syndrome (PMWS)

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