Resistance to β-lactams and quinolones in two isogenic Enterobacter cloacae isolates was studied. One was susceptible to cefoxitin and amoxicillin-clavulanate. The other one showed its natural β-lactam resistance pattern. Both isolates had a nonfunctional AmpR regulator. However, within the second one, the presence of a plasmid carrying ampR and qnrA1 allowed reversion to the wild-type β-lactam resistance phenotype and decreased susceptibility to fluoroauinolones. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - 1 Sep 2006|