In vivo reversion to the wild-type β-lactam resistance phenotype mediated by a plasmid carrying ampR and qnrA1 in Enterobacter cloacae

J. J. González-López, M. Sabaté, S. Lavilla, M. N. Larrosa, R. M. Bartolomé, G. Prats

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Resistance to β-lactams and quinolones in two isogenic Enterobacter cloacae isolates was studied. One was susceptible to cefoxitin and amoxicillin-clavulanate. The other one showed its natural β-lactam resistance pattern. Both isolates had a nonfunctional AmpR regulator. However, within the second one, the presence of a plasmid carrying ampR and qnrA1 allowed reversion to the wild-type β-lactam resistance phenotype and decreased susceptibility to fluoroauinolones. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)3175-3178
JournalAntimicrobial Agents and Chemotherapy
Volume50
DOIs
Publication statusPublished - 1 Sep 2006

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