In vivo changes in the intestinal reflexes and the response to CCK in the inflamed small intestine of the rat

D. Torrents, P. Vergara

    Research output: Contribution to journalArticleResearchpeer-review

    25 Citations (Scopus)

    Abstract

    Functional motor changes and morphological alterations have been associated with intestinal inflammation. The aim of our study was to evaluate functional alterations of intestinal reflexes and of the responses to CCK in the Trichinella spiralis model of intestinal inflammation. Rats were prepared with strain gauges and electrodes in the small intestine to evaluate spontaneous motor activity, the ascending contraction of the peristaltic reflex, and the motor responses to CCK-8 infusion. Infected animals showed increased motor activity at the duodenum and jejunum but not at the ileum. Ascending contraction was increased in both duodenum and ileum. Ascending excitation after Nω-nitro-L-arginine was still increased as well as the residual response after atropine. Response to CCK-8 during intestinal inflammation was changed in the jejunum, in which it turned from the inhibition shown in healthy animals to excitation. NADPH-diaphorase staining did not show any changes between distribution and density of positive neurons in either healthy or infected animals. In conclusion, intestinal inflammation induces functional changes in the motor activity that could explain the abnormal motor responses observed in inflammatory disorders.
    Original languageEnglish
    JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
    Volume279
    Issue number3 42-3
    Publication statusPublished - 5 Oct 2000

    Keywords

    • Ascending contraction
    • Cholecystokinin
    • Intestinal inflammation
    • Nitric oxide

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