In vivo and in vitro relationship between lipoprotein-x and bile salts in cholestasis

J. C. Frisón, M. R. Ras, J. Rubiés-Prat, J. A. Salvá, S. Masdeu, R. Bacardí

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Abstract

Bile salts have been shown to act on lipoprotein-X (LP-X) in vitro to induce a false-negative electrophoretic test. The aim of the present study was to investigate the relationship between serum LP-X and serum bile acids in patients with cholestasis. The in vitro concentration of bile salts required to induce a negative or reduced concentration of LP-X was also studied. There was no relationship, either positive or negative, between serum LP-X and bile acids in 34 patients with cholestasis. Serum was incubated with various saline solutions of taurocholic, lithocholic, deoxycholic and glycocholic acids. The concentration of LP-X decreased only after the final concentrations of bile salts were over 2,000 ¼mol/l. This is more than five times the concentration of serum bile salts usually found in patients with cholestasis. It is concluded that the negative LP-X test in some patients with cholestasis must be explained by some other mechanisms than bile salts. © 1979 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)411-414
JournalDigestion
Volume19
Issue number6
DOIs
Publication statusPublished - 1 Jan 1979

Keywords

  • Bile salts
  • Cholestasis
  • Deoxycholic acid
  • Glycocholic acid
  • Lipoprotein-X
  • Lithocholic acid
  • Taurocholic acid

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    Frisón, J. C., Ras, M. R., Rubiés-Prat, J., Salvá, J. A., Masdeu, S., & Bacardí, R. (1979). In vivo and in vitro relationship between lipoprotein-x and bile salts in cholestasis. Digestion, 19(6), 411-414. https://doi.org/10.1159/000198402