In vitro susceptibility to the sordarin derivative GM 237354 and amphotericin B were tested in a total of 190 Cryptococcus neoformans clinical isolates from different geographical areas of Spain and South American countries. Minimal inhibitory concentrations (MICs) were obtained using the NCCLS reference microbroth dilution method and analysed according the serotypes of Cr. neoformans. The MICs for amphotericin B were lower than 1.0 μg ml1 (MIC90% 0.5 μg ml1, MIC50% 0.125 μg ml1), but five isolates showed MICs of 2.0 μg ml1 to GM 237354 (MIC90% 1.0 μg ml1, MIC50% 0.5 μg ml1). Cryptococcus neoformans var. gattii serotype B, was significantly less susceptible than A and AD serotypes (P = 0.047 and P = 0.022, respectively).
|Publication status||Published - 17 Nov 2002|
- Amphotericin B
- Antifungal susceptibility
- Cryptococcus neoformans