In vitro susceptibilities of bloodstream isolates of Candida species to six antifungal agents: Results from a population-based active surveillance programme, Barcelona, Spain, 2002-2003

Manuel Cuenca-Estrella, Dolores Rodriguez, Benito Almirante, Juliette Morgan, Ana Maria Planes, Manel Almela, José Mensa, Ferran Sanchez, Josefina Ayats, Montserrat Gimenez, Margarita Salvado, David W. Warnock, Albert Pahissa, Juan L. Rodriguez-Tuleda, Scott Fridkin, Rana Hajjeh, Benjamin Park, Francesc Marco Reverter, Melcion Soler, P. SaballsAmadeu Gener, Dionisia Fontanals, Mariona Xercavins, Lluis Falgueras, Marta de Ramon, Maria Teresa Torroella, Carles Alonso, Montserrat Sierra, Joaquin Martinez-Montauti, Maria Antonia Morera, Jordi de Otero

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111 Citations (Scopus)

Abstract

Objectives: The antifungal drug susceptibilities of 351 isolates of Candida species, obtained through active laboratory-based surveillance in the period January 2002-December 2003, were determined (Candida albicans 51%, Candida parapsilosis 23%, Candida tropicalis 10%, Candida glabrata 9%, Candida krusei 4%). Methods: The MICs of amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and caspofungin were established by means of the broth microdilution reference procedure of the European Committee on Antibiotic Susceptibility Testing. Results and conclusions: Amphotericin B and flucytosine were active in vitro against all strains. A total of 24 isolates (6.8%) showed decreased susceptibility to fluconazole (MIC ≥ 16 mg/L) and 43 (12.3%) showed decreased susceptibility to itraconazole (MIC ≥ 0.25 mg/L). Voriconazole and caspofungin were active in vitro against the majority of isolates, even those that were resistant to fluconazole. © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved.
Original languageEnglish
Pages (from-to)194-199
JournalJournal of Antimicrobial Chemotherapy
Volume55
Issue number2
DOIs
Publication statusPublished - 1 Feb 2005

Keywords

  • Caspofungin
  • EUCAST
  • Fluconazole resistance
  • Voriconazole

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