© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Efficient metal-free methods for the electrophilic chlorination of arenes using PIFA and simple chlorine sources are reported. The in situ formation of PhI(Cl)OCOCF 3 from PIFA and KCl is proposed, which resulted in a chlorinating species for moderately activated arenes. Moreover, the in situ formation of PhICl 2 from PIFA and TMSCl resulted in an excellent approach for the chlorination of a great variety of arenes (20 examples) in high yields, even when working on a multigram scale.
|Journal||European Journal of Organic Chemistry|
|Publication status||Published - 8 May 2019|
- Electrophilic chlorination
- I(III) species