Improvement of shuttle-box avoidance with post-training intracranial self-stimulation, in rats: a parametric study

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    Abstract

    Rats were trained in a two-way active avoidance task followed immediately by a lateral hypothalamic intracranial self-stimulation (ICSS) treatment, during 5 consecutive days. The effects of the number of ICSS trains allowed (0, 500, 2500 or 4500) were studied upon acquisition and long-term retention (LTR, 10 and 30 days). The number of ICSS trains administered and the number of avoidances at the last acquisition session (5th) showed a positive lineal relation, that is, the more number of ICSS trains, the more number of avoidances. The level of learning achieved during the 5th session was maintained after the LTR periods in all experimental groups. It is concluded that the number of ICSS trains could be a critical parameter in the facilitatory effect of lateral hypothalamic ICSS upon learning, and it is suggested that the facilitatory effect of post-training lateral hypothalamic ICSS might be due to the activation of general activatory neural systems. © 1991 Elsevier Science Publishers B.V. (Biomedical Division).
    Original languageEnglish
    Pages (from-to)161-167
    JournalBehavioural Brain Research
    Volume42
    Issue number2
    DOIs
    Publication statusPublished - 28 Feb 1991

    Keywords

    • Intracranial self-stimulation: Shuttle-box avoidance
    • Learning
    • Memory

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