Implications of dietary modulation of the arachidonic acid metabolism in psoriasis by means of fish oil rich in eicosapentaenoic acid

L. Puig, L. Vila, C. Gibert, J. M. De Moragas

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    2 Citations (Scopus)

    Abstract

    We studied the metabolism of endogenous arachidonic acid in polymorphonuclear leukocytes and platelets from blood samples obtained at the start and end of the treatment period during a randomized, double blind, 11-week study comparing the effect of daily administration of fish oil rich in eicosapentanoic acid (2,59 g/day) and olive oil in 18 patients with chronic stable plaque psoriasis. After 8 weeks of treatment, we found a statistically significative decrease in 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 12(S)-hydroxy-6,8,10,14-eicosatetraenoic acid (12-HETE) production following 5 minutes' incubation of platelets from patients being treated with fish oil and a significative increase in HHT and 12-HETE production in platelets from patients receiving olive oil capsules, with respect to the values obtained at the beginning of the treatment period.
    Original languageEnglish
    Pages (from-to)117-126
    JournalMedicina Cutanea Ibero-Latino-Americana
    Volume22
    Issue number3
    Publication statusPublished - 20 Jun 1994

    Keywords

    • arachidonic acid
    • diet
    • eicosanoids
    • eicosapentaenoic acid
    • fish oil
    • platelets
    • polymorphonuclear leukocytes
    • psoriasis

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    Puig, L., Vila, L., Gibert, C., & De Moragas, J. M. (1994). Implications of dietary modulation of the arachidonic acid metabolism in psoriasis by means of fish oil rich in eicosapentaenoic acid. Medicina Cutanea Ibero-Latino-Americana, 22(3), 117-126.