An NMR method to enhance the sensitivity and resolution in band-selective long-range heteronuclear correlation spectra is proposed. The excellent in-phase nature of the selHSQMBC experiment allows that homonuclear and/or heteronuclear decoupling can be achieved in the detected dimension of a 2D multiple-bond correlation map, obtaining simplified cross-peaks without their characteristic fine J multiplet structure. The experimental result is a resolution improvement while the highest sensitivity is also achieved. Specifically, it is shown that the 1H-homodecoupled band-selective (HOBS) HSQMBC experiment represents a new way to measure heteronuclear coupling constants from the simplified in-phase doublets generated along the detected dimension. © 2013 Elsevier Inc. All rights reserv.
|Journal||Journal of Magnetic Resonance|
|Publication status||Published - 1 Jan 2014|
- Band-selective HSQMBC
- Homonuclear decoupling
- Proton-carbon coupling constants
- Resolution enhancement
- Sensitivity improvement