Impedimetric DNA Biosensors Based on Nanomaterials

A. Bonanni, M. del Valle

Research output: Chapter in BookChapterResearchpeer-review

1 Citation (Scopus)


© 2014 Scrivener Publishing LLC. All rights reserved. This chapter describes variants of DNA sensors (genosensors) that employ electrochemical impedance signal for detecting a target DNA. In this way, the clinical diagnostic-related sought gene or gene variant can be very simply detected with an electrically addressable device, and potentially, without the use of any label. Existing variants for measuring and the diff erent formats for the assay are presented. To improve the performance of these devices, current nanobiotechnology utilizes nanocomponents, either at the transducer level or integrated in the procedure itself, to improve the detection or to amplify the signal. Carbon nanotubes and nanowires, graphene or gold nanoparticles can be used to produce or to modify transducers, fostering their electrical characteristics, or helping in the immobilization of the recognition element. Metal nanoparticles or even quantum dots may be used to improve signal-to-noise ratio. The chapter ends by summarizing existing applications related to clinical diagnostics and discussing the latest trends.
Original languageEnglish
Title of host publicationBiosensors Nanotechnology
EditorsA. Tiwari, A.P.F. Turner
Place of PublicationSalem (US)
Number of pages29
Publication statusPublished - 21 Jul 2014

Publication series

NameAdvanced Materials Series


  • Carbon nanotube
  • DNA biosensor
  • Electrochemical impedance spectroscopy
  • Genosensor
  • Gold nanoparticles
  • Quantum dots


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