Impaired gamma interferon response to Mycobacterium vaccae antigens in patients with cavitary pulmonary tuberculosis

Elisabeth Rodríguez-Güell, Gemma Agustí, Mercè Corominas, Marina Luquin, Esther Julián

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The ability of tuberculosis patients to recognize Mycobacterium vaccae-specific antigens before starting chemotherapy and according to disease severity was analyzed. We report that the M. vaccae cell wall skeleton fraction triggers more enhanced cytokine production than the whole bacterium. Moreover, a tendency was observed for a lower gamma interferon/interleukin-10 ratio in patients with cavitary disease induced by M. vaccae antigens. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)1485-1488
JournalClinical and Vaccine Immunology
Volume15
DOIs
Publication statusPublished - 1 Sep 2008

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