Impaired endothelial function is not associated with arterial stiffness in adults with type 1 diabetes

G. Llauradó, V. Ceperuelo-Mallafré, C. Vilardell, R. Simó, L. Albert, E. Berlanga, J. Vendrell, J. M. González-Clemente

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8 Citations (Scopus)

Abstract

Aim: This study investigated the relationship between endothelial dysfunction (ED) and arterial stiffness (AS) in adults with type1 diabetes and no clinical cardiovascular (CV) disease. Methods: A total of 68patients with type1 diabetes and 68 age- and gender-matched healthy (non-diabetic) subjects were evaluated. ED was assessed by reactive hyperaemia peripheral arterial tonometry (RH-PAT) and by serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin. AS was assessed by aortic pulse wave velocity (aPWV). All statistical analyses were stratified by gender. Results: Adults with type1 diabetes had RH-PAT index scores similar to those of their matching controls [men: 1.55 (1.38-1.98)% versus 1.61 (1.40-2.17)%, P=0.556; women: 2.07 (1.55-2.31)% versus 2.08 (1.79-2.49)%; P=0.215]. However, after adjusting for potential confounders, type1 diabetes emerged as the main determinant of the RH-PAT index in women. Also, differences between genders in both the controls and type1 diabetes patients disappeared. Men with diabetes had higher serum concentrations of E-selectin, and women had higher serum concentrations of sICAM-1, sVCAM-1 and E-selectin than their respective controls. However, after adjusting for potential confounders, only the differences in sICAM-1 (women) and E-selectin (both genders) remained significant. No association was found between aPWV and the RH-PAT index and ED markers after adjusting for CV risk factors. Conclusion: ED was increased in adults with type1 diabetes compared with age-matched non-diabetic subjects. Also, gender differences in ED were lost in type1 diabetes. However, ED was not associated with AS after adjusting for potential confounders. These findings suggest that ED occurs earlier than AS in type1 diabetes. Objectif: Méthodes: Résultats: Conclusion: © 2013 Elsevier Masson SAS.
Original languageEnglish
Pages (from-to)355-362
JournalDiabetes and Metabolism
Volume39
Issue number4
DOIs
Publication statusPublished - 1 Sep 2013

Keywords

  • Arterial stiffness
  • Endothelial dysfunction
  • Type 1 diabetes

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