Impaired CD4 T-cell response to autophagy in treated HIV-1-infected individuals

Elisabet Gómez-Mora; Véronique Robert-Hebmann; Elisabet García; Marta Massanella; Bonaventura Clotet; Cecilia Cabrera; Julià Blanco; Martine Biard-Piechaczyk

doi:10.1097/QAI.0000000000001201

Impaired CD4 T-cell response to autophagy in treated HIV-1-infected individuals

Elisabet Gómez-Mora, Véronique Robert-Hebmann, Elisabet García, Marta Massanella, Bonaventura Clotet, Cecilia Cabrera, Julià Blanco, Martine Biard-Piechaczyk

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

© 2016 Wolters Kluwer Health, Inc. Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.

Original language	English
Pages (from-to)	201-205
Journal	Journal of acquired immune deficiency syndromes (1999)
Volume	74
Issue number	2
DOIs	https://doi.org/10.1097/QAI.0000000000001201
Publication status	Published - 1 Feb 2017

Keywords

Autophagy
CD4 T cells
HIV-treated individuals
Immunodiscordant individuals
Immunological recovery

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1097/QAI.0000000000001201

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title = "Impaired CD4 T-cell response to autophagy in treated HIV-1-infected individuals",

abstract = "{\textcopyright} 2016 Wolters Kluwer Health, Inc. Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.",

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language = "English",

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Impaired CD4 T-cell response to autophagy in treated HIV-1-infected individuals. / Gómez-Mora, Elisabet; Robert-Hebmann, Véronique; García, Elisabet; Massanella, Marta; Clotet, Bonaventura; Cabrera, Cecilia; Blanco, Julià; Biard-Piechaczyk, Martine.

In: Journal of acquired immune deficiency syndromes (1999), Vol. 74, No. 2, 01.02.2017, p. 201-205.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Impaired CD4 T-cell response to autophagy in treated HIV-1-infected individuals

AU - Gómez-Mora, Elisabet

AU - Robert-Hebmann, Véronique

AU - García, Elisabet

AU - Massanella, Marta

AU - Clotet, Bonaventura

AU - Cabrera, Cecilia

AU - Blanco, Julià

AU - Biard-Piechaczyk, Martine

PY - 2017/2/1

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N2 - © 2016 Wolters Kluwer Health, Inc. Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.

AB - © 2016 Wolters Kluwer Health, Inc. Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.

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KW - CD4 T cells

KW - HIV-treated individuals

KW - Immunodiscordant individuals

KW - Immunological recovery

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