© 2016 Wolters Kluwer Health, Inc. Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.
|Journal||Journal of acquired immune deficiency syndromes (1999)|
|Publication status||Published - 1 Feb 2017|
- CD4 T cells
- HIV-treated individuals
- Immunodiscordant individuals
- Immunological recovery