Impaired CD4 T-cell response to autophagy in treated HIV-1-infected individuals

Elisabet Gómez-Mora, Véronique Robert-Hebmann, Elisabet García, Marta Massanella, Bonaventura Clotet, Cecilia Cabrera, Julià Blanco, Martine Biard-Piechaczyk

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6 Citations (Scopus)

Abstract

© 2016 Wolters Kluwer Health, Inc. Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.
Original languageEnglish
Pages (from-to)201-205
JournalJournal of Acquired Immune Deficiency Syndromes
Volume74
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • Autophagy
  • CD4 T cells
  • HIV-treated individuals
  • Immunodiscordant individuals
  • Immunological recovery

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    Gómez-Mora, E., Robert-Hebmann, V., García, E., Massanella, M., Clotet, B., Cabrera, C., Blanco, J., & Biard-Piechaczyk, M. (2017). Impaired CD4 T-cell response to autophagy in treated HIV-1-infected individuals. Journal of Acquired Immune Deficiency Syndromes, 74(2), 201-205. https://doi.org/10.1097/QAI.0000000000001201