Abstract
© 2016 Wolters Kluwer Health, Inc. Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 201-205 |
| Journal | Journal of Acquired Immune Deficiency Syndromes |
| Volume | 74 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Feb 2017 |
Keywords
- Autophagy
- CD4 T cells
- HIV-treated individuals
- Immunodiscordant individuals
- Immunological recovery
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Cite this
Gómez-Mora, E., Robert-Hebmann, V., García, E., Massanella, M., Clotet, B., Cabrera, C., Blanco, J., & Biard-Piechaczyk, M. (2017). Impaired CD4 T-cell response to autophagy in treated HIV-1-infected individuals. Journal of Acquired Immune Deficiency Syndromes, 74(2), 201-205. https://doi.org/10.1097/QAI.0000000000001201