Impact of the fibromyalgia in the chronic fatigue syndrome

Mónica Faro, Naia Sáez-Francàs, Jesús Castro-Marrero, Luisa Aliste, Antonio Collado, José Alegre

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11 Citations (Scopus)


Background and objective: Different studies have showed association of the chronic fatigue syndrome (CFS) with other pathologies, including fibromyalgia (FM). The objective of this study is to analyze whether there are differences in the clinic and in the assessment of fatigue in CFS patients associated or not with FM. Patients and methods: A cross-sectional, single-site observational study was undertaken on a consecutive cases of a register of CFS patients at CFS Unit in Vall d'Hebron Hospital, Barcelona, from January 2008 until March 2011. The variables analyzed were FM comorbidity, sleep and fatigue characteristics and cognitive, neurological and autonomic symptoms. Questionnaires of fatigue impact scale, fatigue strength and impact on quality of life SF-36 were evaluated. Results: We included 980 CFS patients (mean age: 48 ± 9 years; 91% women). Fibromyalgia was present in 528 patients (54%). The level of fatigue (P =.001) and pain (P <.001) was higher in FM patients. Patients with CFS and FM had more prevalence of sleep-related phenomena. The percentage of patients and the degree of severity of cognitive symptoms, neurological and autonomic dysfunction was higher in FM patients (P <.001). FM patients scored higher on the fatigue impact scale (P <.001) and showed worse results in the quality of life questionnaire (P <.001). Conclusions: FM co-morbidity worse clinical parameters, fatigue and the perception of quality of life in CFS patients. © 2013 Elsevier España, S.L. All rights reserved.
Original languageEnglish
Pages (from-to)519-525
JournalMedicina Clinica
Issue number12
Publication statusPublished - 16 Jun 2014


  • Chronic fatigue syndrome
  • Comorbidity
  • Fibromyalgia
  • Quality of life


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