TY - JOUR
T1 - Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction
AU - Gavara Doñate, Jose
AU - Merenciano, Héctor
AU - Llopis-Lorente, Jordi
AU - Molina-Garcia, Tamara
AU - Perez-Solé, Nerea
AU - de Dios, Elena
AU - Marcos-Garces, Víctor
AU - Monmeneu, José V.
AU - Lopez-Lereu, María P.
AU - Canoves, Joaquim
AU - Bonanad, Clara
AU - Moratal, David
AU - Núñez, Julio
AU - Bayés-Genís, Antoni
AU - Sanchis, Juan
AU - Chorro, Francisco J.
AU - Rios-Navarro, Cesar
AU - Bodi, Vicente
PY - 2024/2/7
Y1 - 2024/2/7
N2 - We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction (STEMI). We enrolled patients discharged for a first anterior reperfused STEMI submitted to undergo CMR. EAT, left ventricular (LV) ejection fraction (LVEF), and IS were quantified at the 1-week (n = 221) and at 6-month CMR (n = 167). At 1-week CMR, mean EAT was 31 ± 13 mL/m
2. Patients with high EAT volume (n = 72) showed larger 1-week IS. After adjustment, EAT extent was independently related to 1-week IS. In patients with large IS at 1 week (>30% of LV mass, n = 88), those with high EAT showed more preserved 6-month LVEF. This association persisted after adjustment and in a 1:1 propensity score-matched patient subset. Overall, EAT decreased at 6 months. In patients with large IS, a greater reduction of EAT was associated with more preserved 6-month LVEF. In STEMI, a higher presence of EAT was associated with a larger IS. Nevertheless, in patients with large infarctions, high EAT and greater subsequent EAT reduction were linked to more preserved LVEF in the chronic phase. This dual and paradoxical effect of EAT fuels the need for further research in this field.
AB - We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction (STEMI). We enrolled patients discharged for a first anterior reperfused STEMI submitted to undergo CMR. EAT, left ventricular (LV) ejection fraction (LVEF), and IS were quantified at the 1-week (n = 221) and at 6-month CMR (n = 167). At 1-week CMR, mean EAT was 31 ± 13 mL/m
2. Patients with high EAT volume (n = 72) showed larger 1-week IS. After adjustment, EAT extent was independently related to 1-week IS. In patients with large IS at 1 week (>30% of LV mass, n = 88), those with high EAT showed more preserved 6-month LVEF. This association persisted after adjustment and in a 1:1 propensity score-matched patient subset. Overall, EAT decreased at 6 months. In patients with large IS, a greater reduction of EAT was associated with more preserved 6-month LVEF. In STEMI, a higher presence of EAT was associated with a larger IS. Nevertheless, in patients with large infarctions, high EAT and greater subsequent EAT reduction were linked to more preserved LVEF in the chronic phase. This dual and paradoxical effect of EAT fuels the need for further research in this field.
KW - Cardiovascular magnetic resonance
KW - Epicardial adipose tissue
KW - Infarct size
KW - Left ventricular ejection fraction
KW - ST-segment elevation myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=85187267564&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/1af5bca6-a184-3f9b-86a3-7af668e0e02c/
U2 - 10.3390/diagnostics14040368
DO - 10.3390/diagnostics14040368
M3 - Article
C2 - 38396407
SN - 2075-4418
VL - 14
JO - Diagnostics
JF - Diagnostics
IS - 4
M1 - 368
ER -