Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging

Lidia Castillo-Mariqueo; Lydia Giménez-Llort

doi:10.3390/biomedicines10050973

Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging

Lidia Castillo-Mariqueo, Lydia Giménez-Llort^*

^*Corresponding author for this work

Universitat Autònoma de Barcelona (UAB)

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Longitudinal approaches for disease-monitoring in old animals face survival and frailty limitations, but also assessment and re-test bias on genotype and sex effects. The present work investigated these effects on 56 variables for behavior, functional profile, and biological status of male and female 3xTg-AD mice and NTg counterparts using two designs: (1) a longitudinal de-sign: naïve 12-month-old mice re-tested four months later; and (2) a cross-sectional design: naïve 16-month-old mice compared to those re-tested. The results confirmed the impact as (1) improve-ment of survival (NTg rested females), variability of gait (3xTg-AD 16-month-old re-tested and naïve females), physical endurance (3xTg-AD re-tested females), motor learning (3xTg-AD and NTg 16-month-old re-tested females), and geotaxis (3xTg-AD naïve 16-month-old males); but (2) worse anxiety (3xTg-AD 16-month-old re-tested males), HPA axis (3xTg-AD 16-month-old re-tested and naïve females) and sarcopenia (3xTg-AD 16-month-old naïve females). Males showed more functional correlations than females. The functional profile, biological status, and their correlation are discussed as relevant elements for AD-pathology. Therefore, repetition of behavioral batteries could be considered training by itself, with some variables sensitive to genotype, sex, and re-test. In the AD-genotype, females achieved the best performance in physical endurance and motor learning, while males showed a deterioration in most studied variables.

Original language	English
Article number	973
Journal	Biomedicines
Volume	10
Issue number	5
DOIs	https://doi.org/10.3390/biomedicines10050973
Publication status	Published - May 2022

Keywords

Aging
Alzheimer’s disease
Anxious profile
Frailty
Functional profile
Gait analysis
Motor perfor-mance
Survival
Training
kyphosis

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ARRESTAD: 3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer's neurodegeneration (ARRESTAD)
Gimenez Llort, L. (Principal Investigator), SORIA AIDA, M. (Collaborator) & Muntsant Soria, A. (Investigator)
European Commission (EC)
1/01/17 → 31/05/22
Project: International research project

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title = "Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging",

abstract = "Longitudinal approaches for disease-monitoring in old animals face survival and frailty limitations, but also assessment and re-test bias on genotype and sex effects. The present work investigated these effects on 56 variables for behavior, functional profile, and biological status of male and female 3xTg-AD mice and NTg counterparts using two designs: (1) a longitudinal de-sign: na{\"i}ve 12-month-old mice re-tested four months later; and (2) a cross-sectional design: na{\"i}ve 16-month-old mice compared to those re-tested. The results confirmed the impact as (1) improve-ment of survival (NTg rested females), variability of gait (3xTg-AD 16-month-old re-tested and na{\"i}ve females), physical endurance (3xTg-AD re-tested females), motor learning (3xTg-AD and NTg 16-month-old re-tested females), and geotaxis (3xTg-AD na{\"i}ve 16-month-old males); but (2) worse anxiety (3xTg-AD 16-month-old re-tested males), HPA axis (3xTg-AD 16-month-old re-tested and na{\"i}ve females) and sarcopenia (3xTg-AD 16-month-old na{\"i}ve females). Males showed more functional correlations than females. The functional profile, biological status, and their correlation are discussed as relevant elements for AD-pathology. Therefore, repetition of behavioral batteries could be considered training by itself, with some variables sensitive to genotype, sex, and re-test. In the AD-genotype, females achieved the best performance in physical endurance and motor learning, while males showed a deterioration in most studied variables.",

keywords = "Aging, Alzheimer{\textquoteright}s disease, Anxious profile, Frailty, Functional profile, Gait analysis, Motor perfor-mance, Survival, Training, kyphosis",

author = "Lidia Castillo-Mariqueo and Lydia Gim{\'e}nez-Llort",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

doi = "10.3390/biomedicines10050973",

language = "English",

volume = "10",

journal = "Biomedicines",

issn = "2227-9059",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "5",

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Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging. / Castillo-Mariqueo, Lidia; Giménez-Llort, Lydia.
In: Biomedicines, Vol. 10, No. 5, 973, 05.2022.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

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AU - Castillo-Mariqueo, Lidia

AU - Giménez-Llort, Lydia

PY - 2022/5

Y1 - 2022/5

N2 - Longitudinal approaches for disease-monitoring in old animals face survival and frailty limitations, but also assessment and re-test bias on genotype and sex effects. The present work investigated these effects on 56 variables for behavior, functional profile, and biological status of male and female 3xTg-AD mice and NTg counterparts using two designs: (1) a longitudinal de-sign: naïve 12-month-old mice re-tested four months later; and (2) a cross-sectional design: naïve 16-month-old mice compared to those re-tested. The results confirmed the impact as (1) improve-ment of survival (NTg rested females), variability of gait (3xTg-AD 16-month-old re-tested and naïve females), physical endurance (3xTg-AD re-tested females), motor learning (3xTg-AD and NTg 16-month-old re-tested females), and geotaxis (3xTg-AD naïve 16-month-old males); but (2) worse anxiety (3xTg-AD 16-month-old re-tested males), HPA axis (3xTg-AD 16-month-old re-tested and naïve females) and sarcopenia (3xTg-AD 16-month-old naïve females). Males showed more functional correlations than females. The functional profile, biological status, and their correlation are discussed as relevant elements for AD-pathology. Therefore, repetition of behavioral batteries could be considered training by itself, with some variables sensitive to genotype, sex, and re-test. In the AD-genotype, females achieved the best performance in physical endurance and motor learning, while males showed a deterioration in most studied variables.

AB - Longitudinal approaches for disease-monitoring in old animals face survival and frailty limitations, but also assessment and re-test bias on genotype and sex effects. The present work investigated these effects on 56 variables for behavior, functional profile, and biological status of male and female 3xTg-AD mice and NTg counterparts using two designs: (1) a longitudinal de-sign: naïve 12-month-old mice re-tested four months later; and (2) a cross-sectional design: naïve 16-month-old mice compared to those re-tested. The results confirmed the impact as (1) improve-ment of survival (NTg rested females), variability of gait (3xTg-AD 16-month-old re-tested and naïve females), physical endurance (3xTg-AD re-tested females), motor learning (3xTg-AD and NTg 16-month-old re-tested females), and geotaxis (3xTg-AD naïve 16-month-old males); but (2) worse anxiety (3xTg-AD 16-month-old re-tested males), HPA axis (3xTg-AD 16-month-old re-tested and naïve females) and sarcopenia (3xTg-AD 16-month-old naïve females). Males showed more functional correlations than females. The functional profile, biological status, and their correlation are discussed as relevant elements for AD-pathology. Therefore, repetition of behavioral batteries could be considered training by itself, with some variables sensitive to genotype, sex, and re-test. In the AD-genotype, females achieved the best performance in physical endurance and motor learning, while males showed a deterioration in most studied variables.

KW - Aging

KW - Alzheimer’s disease

KW - Anxious profile

KW - Frailty

KW - Functional profile

KW - Gait analysis

KW - Motor perfor-mance

KW - Survival

KW - Training

KW - kyphosis

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DO - 10.3390/biomedicines10050973

M3 - Article

C2 - 35625710

AN - SCOPUS:85129606148

SN - 2227-9059

VL - 10

JO - Biomedicines

JF - Biomedicines

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M1 - 973

ER -

Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging

Abstract

Keywords

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ARRESTAD: 3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer's neurodegeneration (ARRESTAD)

Cite this