Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis

Pere Joan Cardona, Isabel Amat, Sergi Gordillo, Virginia Arcos, Evelyn Guirado, Jorge Díaz, Cristina Vilaplana, Gustavo Tapia, Vicenç Ausina

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66 Citations (Scopus)

Abstract

Reduction of colony forming units by rifampicin-isoniazid therapy given 9-17 weeks post-infection was made more pronounced by immunotherapy with a vaccine made of fragmented Mycobacterium tuberculosis cells detoxified and liposomed (RUTI), given on weeks 17, 19 and 21 post-infection, in the murine model of tuberculosis in C57BL/6 and DBA/2 inbred strains. RUTI triggered a Th1/Th2 response, as demonstrated by the production of IgG1, IgG2a and IgG3 antibodies against a wide range of peptides. The histological analysis did not show neither eosinophilia nor necrosis, and granulomatous infiltration was only slightly increased in C57BL/6 mice when RUTI was administered intranasally. © 2004 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)1393-1398
JournalVaccine
Volume23
DOIs
Publication statusPublished - 3 Feb 2005

Keywords

  • Chemotherapy
  • Histological analysis
  • Immunotherapy

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