Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms

Maria Salvador-Mira, Veronica Chico, Monica Arostica, Fanny Guzmán, Nerea Roher, Luis Perez, Maria Del Mar Ortega-Villaizan*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

One of the challenges of science in disease prevention is optimizing drug and vaccine delivery. Until now, many strategies have been employed in this sector, but most are quite complex and labile. To overcome these limitations, great efforts are directed to coupling drugs to carriers, either of natural or synthetic origin. Among the most studied cell carriers are antigen-presenting cells (APCs), however, red blood cells (RBCs) are positioned as attractive carriers in drug delivery due to their abundance and availability in the body. Furthermore, fish RBCs have a nucleus and have been shown to have a strong involvement in modulating the immune response. In this study, we evaluated the binding of three peptides to rainbow trout RBCs, two lectin-like peptides and another derived from Plasmodium falciparum membrane protein, in order to take advantage of this peptide-RBCs binding to generate tools to improve the specificity, efficacy, immunostimulatory ef-fect, and safety of the antiviral therapeutic or prophylactic administration systems currently used.

Original languageEnglish
Article number11821
JournalInternational journal of molecular sciences
Volume22
Issue number21
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • Cell-targeting
  • Drug delivery
  • Erythrocyte
  • Fish
  • Lectin
  • Ligand
  • Peptide
  • Prophylactic
  • Red blood cells
  • Therapeutic

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