TY - JOUR
T1 - Immunohistochemical study of aquaporins in an African grey parrot (Psittacus erithacus) with hydrocephalus
AU - Pumarola Batlle, Martí
AU - Blasco Ortega, Ester
AU - Martorell Montserrat, Jaime Miguel
AU - De La Fuente Hernandez, Cristian
PY - 2014/1/1
Y1 - 2014/1/1
N2 - © 2014 by the Association of Avian Veterinarians. A 5-month-old African grey parrot (Psittacus erithacus) was examined after 3 weeks of weakness, ataxia, mental depression, and seizures. Results of a complete blood cell count and plasma biochemical analysis were unremarkable. Magnetic resonance imaging revealed a severe bilateral hydrocephalus. The bird failed to improve with supportive care, and the owner requested euthanasia. Necropsy findings were severe bilateral hydrocephalus with no evidence of cerebrospinal fluid obstruction. Histologic examination of the brain revealed microspongiosis, edema, gliosis, and neuronal chromatolysis of surrounding periventricular tissue. Aquaporins (AQP) and astrocytes were examined to elucidate the participation of these water channel proteins and glial cells in the pathophysiology and resolution of hydrocephalus. Results showed AQP4 and glial fibrillary acidic protein were overexpressed, especially near the ventricles, but expression of AQP1 was decreased. This is the first report, to our knowledge, of AQP immunolabeling in hydrocephalus in avain species.
AB - © 2014 by the Association of Avian Veterinarians. A 5-month-old African grey parrot (Psittacus erithacus) was examined after 3 weeks of weakness, ataxia, mental depression, and seizures. Results of a complete blood cell count and plasma biochemical analysis were unremarkable. Magnetic resonance imaging revealed a severe bilateral hydrocephalus. The bird failed to improve with supportive care, and the owner requested euthanasia. Necropsy findings were severe bilateral hydrocephalus with no evidence of cerebrospinal fluid obstruction. Histologic examination of the brain revealed microspongiosis, edema, gliosis, and neuronal chromatolysis of surrounding periventricular tissue. Aquaporins (AQP) and astrocytes were examined to elucidate the participation of these water channel proteins and glial cells in the pathophysiology and resolution of hydrocephalus. Results showed AQP4 and glial fibrillary acidic protein were overexpressed, especially near the ventricles, but expression of AQP1 was decreased. This is the first report, to our knowledge, of AQP immunolabeling in hydrocephalus in avain species.
KW - African grey parrot
KW - AQP
KW - aquaporin
KW - avian
KW - cerebrospinal fluid
KW - CSF
KW - hydrocephalus
KW - Psittacus erithacus
U2 - 10.1647/2013-059
DO - 10.1647/2013-059
M3 - Article
VL - 28
SP - 309
EP - 315
JO - Journal of Avian Medicine and Surgery
JF - Journal of Avian Medicine and Surgery
SN - 1082-6742
IS - 4
ER -