Immunohistochemical study of aquaporins in an African grey parrot (Psittacus erithacus) with hydrocephalus

Martí Pumarola Batlle, Ester Blasco Ortega, Jaime Miguel Martorell Montserrat, Cristian De La Fuente Hernandez

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

© 2014 by the Association of Avian Veterinarians. A 5-month-old African grey parrot (Psittacus erithacus) was examined after 3 weeks of weakness, ataxia, mental depression, and seizures. Results of a complete blood cell count and plasma biochemical analysis were unremarkable. Magnetic resonance imaging revealed a severe bilateral hydrocephalus. The bird failed to improve with supportive care, and the owner requested euthanasia. Necropsy findings were severe bilateral hydrocephalus with no evidence of cerebrospinal fluid obstruction. Histologic examination of the brain revealed microspongiosis, edema, gliosis, and neuronal chromatolysis of surrounding periventricular tissue. Aquaporins (AQP) and astrocytes were examined to elucidate the participation of these water channel proteins and glial cells in the pathophysiology and resolution of hydrocephalus. Results showed AQP4 and glial fibrillary acidic protein were overexpressed, especially near the ventricles, but expression of AQP1 was decreased. This is the first report, to our knowledge, of AQP immunolabeling in hydrocephalus in avain species.
Original languageEnglish
Pages (from-to)309-315
JournalJournal of Avian Medicine and Surgery
Volume28
Issue number4
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • African grey parrot
  • AQP
  • aquaporin
  • avian
  • cerebrospinal fluid
  • CSF
  • hydrocephalus
  • Psittacus erithacus

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