Immunohistochemical localization of the sigma1 receptor in Schwann cells of rat sciatic nerve

Gabriel Palacios, Asunción Muro, Enric Verdú, Martí Pumarola, José Miguel Vela

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38 Citations (Scopus)


The sigma-1 (σ1) receptors can bind different psychotropic drugs and have been implicated in schizophrenia, depression and dementia. The cloning of the σ1-receptor has allowed to obtain specific antibodies and, in a recent immunohistochemical study, we demonstrated that, in addition to neurons, the σ1-receptor is located in oligodendrocytes [Brain Res. 961 (2003) 92.]. In the present study using in vivo and in vitro techniques, we demonstrate the localization of the σ1-receptor in Schwann cells. Double immunofluorescence studies showed that σ1-receptor co-localized with S100 protein, a specific marker of Schwann cells, in both rat sciatic nerve Schwann cells and Schwann cells in cultures. The σ1-receptor immunoreactivity was seen in the cytoplasm and paranodal region formed by these cells, but not in myelin itself. The presence of σ1-receptor in oligodendrocytes and Schwann cells is discussed on the basis on recent findings involving this receptor in lipid metabolism, compartmentalization and transport to the plasma membrane, thus suggesting a role for σ1-receptor signaling in myelination. © 2004 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalBrain Research
Issue number1-2
Publication statusPublished - 8 May 2004


  • Cellular and molecular biology
  • Immunohistochemistry
  • Myelination
  • Neuroglia and myelin
  • Rat sciatic nerve
  • Schwann cell
  • Sigma (σ)-receptor


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