Immunohistochemical localization of the σ<inf>1</inf>-receptor in oligodendrocytes in the rat central nervous system

Gabriel Palacios, Asunción Muro, José Miguel Vela, Eduardo Molina-Holgado, Xavier Guitart, Sergio Ovalle, Daniel Zamanillo

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Abstract

By using a new polyclonal antibody raised against a 21-amino acid peptide sequence corresponding to the fragment 138-157 of the cloned rat σ1-receptor, we demonstrated by immunoperoxidase and double immunofluorescence techniques, that rat oligodendrocytes express the σ1-receptor. Experiments in vivo and in vitro showed that σ1-receptor colocalized with specific markers of progenitor (A2B5) and mature oligodendrocytes (GalC, RIP). These results suggest that σ1-receptor in oligodendrocytes might be involved in myelination by direct implication in cholesterol biosynthesis or by interaction with endogenous ligands such as neurosteroids. © 2002 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)92-99
JournalBrain Research
Volume961
Issue number1
DOIs
Publication statusPublished - 24 Jan 2003

Keywords

  • Immunohistochemistry
  • Oligodendrocytes
  • Rat brain
  • Sigma (σ )-receptor 1 1

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    Palacios, G., Muro, A., Vela, J. M., Molina-Holgado, E., Guitart, X., Ovalle, S., & Zamanillo, D. (2003). Immunohistochemical localization of the σ<inf>1</inf>-receptor in oligodendrocytes in the rat central nervous system. Brain Research, 961(1), 92-99. https://doi.org/10.1016/S0006-8993(02)03892-1