By using a new polyclonal antibody raised against a 21-amino acid peptide sequence corresponding to the fragment 138-157 of the cloned rat σ1-receptor, we demonstrated by immunoperoxidase and double immunofluorescence techniques, that rat oligodendrocytes express the σ1-receptor. Experiments in vivo and in vitro showed that σ1-receptor colocalized with specific markers of progenitor (A2B5) and mature oligodendrocytes (GalC, RIP). These results suggest that σ1-receptor in oligodendrocytes might be involved in myelination by direct implication in cholesterol biosynthesis or by interaction with endogenous ligands such as neurosteroids. © 2002 Elsevier Science B.V. All rights reserved.
|Publication status||Published - 24 Jan 2003|
- Rat brain
- Sigma (σ )-receptor 1 1