Immunohistochemical expression of p53, p21, p16, and cyclin D1 in superficial bladder cancer. A tissue microarray study

F. R. Vallmanya Llena, A. Laborda Rodríguez, J. Lloreta Trull, R. Cortadella Ángel, J. Placer Santos, A. Gelabert Mas

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12 Citations (Scopus)


Introduction and objectivest: To retrospectively assess the relationship between immunohistochemical expression of p53, p21, p 16, and cyclin D1, with recurrence, progression and survival in superficial bladder cancer. Methods: 163 patients undergoing transurethral resection for superficial bladder cancer between February 1995 and March 2004. Tumor samples were included in a tissue microarray support that was serially sectioned for immunohistochemical staining. Grade and stage associations for each marker were evaluated by the Chi-square test. Assessment of the relationship with recurrence, progression, and survival Kaplan-Meier curves and log-rank test were used. Results: There were no statistically significant differences in marker expression depending an tumor grade and stage, with the exception of Cyclin D1, that was significantly different depending on tumor stage (p=0.030). p21 expression was related to tumor recurrence (p=0.035), progression (p=0.008) and survival (p=0.034). p16 expression was also related to recurrence (p=0.048) and survival (p=0.047), but not to tumor progression (p=0.116). p53 and Cyclin D1 were not statistically associated with tumor recurrence, progression or survival. Conclusions: In our experience, only p16 and p21 may be useful in the management of superficial bladder tumors, as they are predictors of recurrence and survival in Ta and T1 patients.
Original languageEnglish
Pages (from-to)754-762
JournalActas Urologicas Espanolas
Issue number8
Publication statusPublished - 1 Jan 2006


  • Cyclin D1
  • p16
  • p21
  • p53
  • Tissue microarray
  • Urothelial carcinoma


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