Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1

Christoph T. Berger, Anuska Llano, Jonathan M. Carlson, Zabrina L. Brumme, Mark A. Brockman, Samandhy Cedeño, P. Richard Harrigan, Daniel E. Kaufmann, David Heckerman, Andreas Meyerhans, Christian Brander

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

© 2015, American Society for Microbiology. Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is unknown. Using sequence alignments and computational approaches, we here predict five potential antisense HIV proteins and characterize common CTL responses against them. Results suggest that antisense-derived sequences are commonly transcribed and translated and could encode functional proteins that contain important targets of anti-HIV cellular immunity.
Original languageEnglish
Pages (from-to)4015-4019
JournalJournal of Virology
Volume89
Issue number7
DOIs
Publication statusPublished - 1 Jan 2015

Fingerprint Dive into the research topics of 'Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1'. Together they form a unique fingerprint.

  • Cite this

    Berger, C. T., Llano, A., Carlson, J. M., Brumme, Z. L., Brockman, M. A., Cedeño, S., Richard Harrigan, P., Kaufmann, D. E., Heckerman, D., Meyerhans, A., & Brander, C. (2015). Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1. Journal of Virology, 89(7), 4015-4019. https://doi.org/10.1128/JVI.03435-14