Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Ana Gutiérrez Casbas; Pedro Zapater; Elena Ricart; María González-Vivó; Jordi Gordillo; David Olivares; Isabel Vera; Míriam Mañosa i Ciria; Javier P. Gisbert; Mariam Aguas; Eugenia Sánchez-Rodríguez; Maia Bosca-Watts; Viviana Laredo; Blau Camps; Ignacio Marín-Jiménez; Yamile Zabana; María Dolores Martín-Arranz; Roser Muñoz; Mercè Navarro; Eva Sierra; Lucía Madero; Milagros Vela; José Lázaro Pérez-Calle; Empar Sainz; Xavier Calvet Calvo; Lara Arias García; Victor Morales; Fernando Bermejo; Luis Fernández-Salazar; Manuel Van Domselaar; Luisa De Castro; Cristina Rodríguez; Carmen Muñoz-Villafranca; Rufo Lorente; Montserrat Rivero; Eva Iglesias; Belén Herreros Martínez; David Busquets; Joan Riera; María Pilar Martínez-Montiel; Marta Roldón; Oscar Roncero; Esther Hinojosa; Mónica Sierra Ausín; Jesús Barrio; Ruth de Francisco; José María Huguet; Olga Merino; Daniel Carpio; Daniel Ginard; Fernando Muñoz; Marta Piqueras; Pedro Almela; Federico Argüelles-Arias; Guillermo Alcaín; Luis Bujanda; Noemí Manceñido; Alfredo J. Lucendo; Pilar Varela; Iago Rodríguez-Lago; Laura Ramos López; Laura Sempere; Eva Sesé; Manuel Barreiro de-Acosta; Eugeni Domènech; Rubén Francés

doi:10.3389/fmed.2022.823900

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Ana Gutiérrez Casbas, Pedro Zapater, Elena Ricart, María González-Vivó, Jordi Gordillo, David Olivares, Isabel Vera, Míriam Mañosa i Ciria, Javier P. Gisbert, Mariam Aguas, Eugenia Sánchez-Rodríguez, Maia Bosca-Watts, Viviana Laredo, Blau Camps, Ignacio Marín-Jiménez, Yamile Zabana, María Dolores Martín-Arranz, Roser Muñoz, Mercè Navarro, Eva SierraLucía Madero, Milagros Vela, José Lázaro Pérez-Calle, Empar Sainz, Xavier Calvet Calvo, Lara Arias García, Victor Morales, Fernando Bermejo, Luis Fernández-Salazar, Manuel Van Domselaar, Luisa De Castro, Cristina Rodríguez, Carmen Muñoz-Villafranca, Rufo Lorente, Montserrat Rivero, Eva Iglesias, Belén Herreros Martínez, David Busquets, Joan Riera, María Pilar Martínez-Montiel, Marta Roldón, Oscar Roncero, Esther Hinojosa, Mónica Sierra Ausín, Jesús Barrio, Ruth de Francisco, José María Huguet, Olga Merino, Daniel Carpio, Daniel Ginard, Fernando Muñoz, Marta Piqueras, Pedro Almela, Federico Argüelles-Arias, Guillermo Alcaín, Luis Bujanda, Noemí Manceñido, Alfredo J. Lucendo, Pilar Varela, Iago Rodríguez-Lago, Laura Ramos López, Laura Sempere, Eva Sesé, Manuel Barreiro de-Acosta, Eugeni Domènech, Rubén Francés

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

Original language	English
Journal	Frontiers in Medicine
Volume	9
DOIs	https://doi.org/10.3389/fmed.2022.823900
Publication status	Published - 2022

Keywords

Immigrant
Phenotype
Biologics
Inflammatory bowel disease
Crohn's disease
Ulcerative colitis

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10.3389/fmed.2022.823900

https://ddd.uab.cat/record/256078Licence: CC BY

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Gutiérrez Casbas, A., Zapater, P., Ricart, E., González-Vivó, M., Gordillo, J., Olivares, D., Vera, I., Mañosa i Ciria, M., P. Gisbert, J., Aguas, M., Sánchez-Rodríguez, E., Bosca-Watts, M., Laredo, V., Camps, B., Marín-Jiménez, I., Zabana, Y., Martín-Arranz, M. D., Muñoz, R., Navarro, M., ... Francés, R. (2022). Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.823900

@article{821ec95bac7443abb09fee6051f53a6f,

title = "Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients",

abstract = "Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.",

keywords = "Immigrant, Phenotype, Biologics, Inflammatory bowel disease, Crohn's disease, Ulcerative colitis",

author = "{Guti{\'e}rrez Casbas}, Ana and Pedro Zapater and Elena Ricart and Mar{\'i}a Gonz{\'a}lez-Viv{\'o} and Jordi Gordillo and David Olivares and Isabel Vera and {Ma{\~n}osa i Ciria}, M{\'i}riam and {P. Gisbert}, Javier and Mariam Aguas and Eugenia S{\'a}nchez-Rodr{\'i}guez and Maia Bosca-Watts and Viviana Laredo and Blau Camps and Ignacio Mar{\'i}n-Jim{\'e}nez and Yamile Zabana and Mart{\'i}n-Arranz, {Mar{\'i}a Dolores} and Roser Mu{\~n}oz and Merc{\`e} Navarro and Eva Sierra and Luc{\'i}a Madero and Milagros Vela and P{\'e}rez-Calle, {Jos{\'e} L{\'a}zaro} and Empar Sainz and {Calvet Calvo}, Xavier and {Arias Garc{\'i}a}, Lara and Victor Morales and Fernando Bermejo and Luis Fern{\'a}ndez-Salazar and {Van Domselaar}, Manuel and {De Castro}, Luisa and Cristina Rodr{\'i}guez and Carmen Mu{\~n}oz-Villafranca and Rufo Lorente and Montserrat Rivero and Eva Iglesias and {Herreros Mart{\'i}nez}, Bel{\'e}n and David Busquets and Joan Riera and Mart{\'i}nez-Montiel, {Mar{\'i}a Pilar} and Marta Rold{\'o}n and Oscar Roncero and Esther Hinojosa and {Sierra Aus{\'i}n}, M{\'o}nica and Jes{\'u}s Barrio and {de Francisco}, Ruth and Huguet, {Jos{\'e} Mar{\'i}a} and Olga Merino and Daniel Carpio and Daniel Ginard and Fernando Mu{\~n}oz and Marta Piqueras and Pedro Almela and Federico Arg{\"u}elles-Arias and Guillermo Alca{\'i}n and Luis Bujanda and Noem{\'i} Mance{\~n}ido and Lucendo, {Alfredo J.} and Pilar Varela and Iago Rodr{\'i}guez-Lago and {Ramos L{\'o}pez}, Laura and Laura Sempere and Eva Ses{\'e} and {Barreiro de-Acosta}, Manuel and Eugeni Dom{\`e}nech and Rub{\'e}n Franc{\'e}s",

year = "2022",

doi = "10.3389/fmed.2022.823900",

language = "English",

volume = "9",

journal = "Frontiers in Medicine",

issn = "2296-858X",

publisher = "Frontiers Media S.A.",

}

Gutiérrez Casbas, A, Zapater, P, Ricart, E, González-Vivó, M, Gordillo, J, Olivares, D, Vera, I, Mañosa i Ciria, M, P. Gisbert, J, Aguas, M, Sánchez-Rodríguez, E, Bosca-Watts, M, Laredo, V, Camps, B, Marín-Jiménez, I, Zabana, Y, Martín-Arranz, MD, Muñoz, R, Navarro, M, Sierra, E, Madero, L, Vela, M, Pérez-Calle, JL, Sainz, E, Calvet Calvo, X, Arias García, L, Morales, V, Bermejo, F, Fernández-Salazar, L, Van Domselaar, M, De Castro, L, Rodríguez, C, Muñoz-Villafranca, C, Lorente, R, Rivero, M, Iglesias, E, Herreros Martínez, B, Busquets, D, Riera, J, Martínez-Montiel, MP, Roldón, M, Roncero, O, Hinojosa, E, Sierra Ausín, M, Barrio, J, de Francisco, R, Huguet, JM, Merino, O, Carpio, D, Ginard, D, Muñoz, F, Piqueras, M, Almela, P, Argüelles-Arias, F, Alcaín, G, Bujanda, L, Manceñido, N, Lucendo, AJ, Varela, P, Rodríguez-Lago, I, Ramos López, L, Sempere, L, Sesé, E, Barreiro de-Acosta, M, Domènech, E & Francés, R 2022, 'Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients', Frontiers in Medicine, vol. 9. https://doi.org/10.3389/fmed.2022.823900

TY - JOUR

T1 - Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

AU - Gutiérrez Casbas, Ana

AU - Zapater, Pedro

AU - Ricart, Elena

AU - González-Vivó, María

AU - Gordillo, Jordi

AU - Olivares, David

AU - Vera, Isabel

AU - Mañosa i Ciria, Míriam

AU - P. Gisbert, Javier

AU - Aguas, Mariam

AU - Sánchez-Rodríguez, Eugenia

AU - Bosca-Watts, Maia

AU - Laredo, Viviana

AU - Camps, Blau

AU - Marín-Jiménez, Ignacio

AU - Zabana, Yamile

AU - Martín-Arranz, María Dolores

AU - Muñoz, Roser

AU - Navarro, Mercè

AU - Sierra, Eva

AU - Madero, Lucía

AU - Vela, Milagros

AU - Pérez-Calle, José Lázaro

AU - Sainz, Empar

AU - Calvet Calvo, Xavier

AU - Arias García, Lara

AU - Morales, Victor

AU - Bermejo, Fernando

AU - Fernández-Salazar, Luis

AU - Van Domselaar, Manuel

AU - De Castro, Luisa

AU - Rodríguez, Cristina

AU - Muñoz-Villafranca, Carmen

AU - Lorente, Rufo

AU - Rivero, Montserrat

AU - Iglesias, Eva

AU - Herreros Martínez, Belén

AU - Busquets, David

AU - Riera, Joan

AU - Martínez-Montiel, María Pilar

AU - Roldón, Marta

AU - Roncero, Oscar

AU - Hinojosa, Esther

AU - Sierra Ausín, Mónica

AU - Barrio, Jesús

AU - de Francisco, Ruth

AU - Huguet, José María

AU - Merino, Olga

AU - Carpio, Daniel

AU - Ginard, Daniel

AU - Muñoz, Fernando

AU - Piqueras, Marta

AU - Almela, Pedro

AU - Argüelles-Arias, Federico

AU - Alcaín, Guillermo

AU - Bujanda, Luis

AU - Manceñido, Noemí

AU - Lucendo, Alfredo J.

AU - Varela, Pilar

AU - Rodríguez-Lago, Iago

AU - Ramos López, Laura

AU - Sempere, Laura

AU - Sesé, Eva

AU - Barreiro de-Acosta, Manuel

AU - Domènech, Eugeni

AU - Francés, Rubén

PY - 2022

Y1 - 2022

N2 - Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

AB - Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

KW - Immigrant

KW - Phenotype

KW - Biologics

KW - Inflammatory bowel disease

KW - Crohn's disease

KW - Ulcerative colitis

U2 - 10.3389/fmed.2022.823900

DO - 10.3389/fmed.2022.823900

M3 - Article

C2 - 35178413

SN - 2296-858X

VL - 9

JO - Frontiers in Medicine

JF - Frontiers in Medicine

ER -

Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

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Keywords

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