Imipramine and desipramine dcrease the gaba-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats

A. Fernändez-Teruel; R. M. Escorihuela; F. Iioix; B. Longoni; M. G. Corda; A. Tobena

doi:https://doi.org/10.1159/000119442

Imipramine and desipramine dcrease the gaba-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats

A. Fernändez-Teruel, R. M. Escorihuela, F. Iioix, B. Longoni, M. G. Corda, A. Tobena

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated³⁶CL uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B and 3A. B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action. © 1990 S. Karger AG, Basel.

Original language	English
Pages (from-to)	147-152
Journal	Neuropsychobiology
Volume	23
DOIs	https://doi.org/10.1159/000119442
Publication status	Published - 1 Jan 1990

Keywords

36CL uptake
Antidepressants
Forced swimming test
Pentylenetetrazol
Picrotoxin

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title = "Imipramine and desipramine dcrease the gaba-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats",

abstract = "The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated36CL uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B and 3A. B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action. {\textcopyright} 1990 S. Karger AG, Basel.",

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year = "1990",

month = jan,

day = "1",

doi = "https://doi.org/10.1159/000119442",

language = "English",

volume = "23",

pages = "147--152",

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Imipramine and desipramine dcrease the gaba-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats. / Fernändez-Teruel, A.; Escorihuela, R. M.; Iioix, F.; Longoni, B.; Corda, M. G.; Tobena, A.

In: Neuropsychobiology, Vol. 23, 01.01.1990, p. 147-152.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Imipramine and desipramine dcrease the gaba-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats

AU - Fernändez-Teruel, A.

AU - Escorihuela, R. M.

AU - Iioix, F.

AU - Longoni, B.

AU - Corda, M. G.

AU - Tobena, A.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated36CL uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B and 3A. B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action. © 1990 S. Karger AG, Basel.

AB - The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated36CL uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B and 3A. B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action. © 1990 S. Karger AG, Basel.

KW - 36CL uptake

KW - Antidepressants

KW - Forced swimming test

KW - Pentylenetetrazol

KW - Picrotoxin

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DO - https://doi.org/10.1159/000119442

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