Imipramine and desipramine dcrease the gaba-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats

A. Fernändez-Teruel, R. M. Escorihuela, F. Iioix, B. Longoni, M. G. Corda, A. Tobena

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19 Citations (Scopus)

Abstract

The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated36CL uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B and 3A. B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action. © 1990 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)147-152
JournalNeuropsychobiology
Volume23
DOIs
Publication statusPublished - 1 Jan 1990

Keywords

  • 36CL uptake
  • Antidepressants
  • Forced swimming test
  • Pentylenetetrazol
  • Picrotoxin

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