The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated36CL uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B and 3A. B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action. © 1990 S. Karger AG, Basel.
|Publication status||Published - 1 Jan 1990|
- 36CL uptake
- Forced swimming test