Imaging of cellular aging in human retinal blood vessels

J. Catita; M. López-Luppo; D. Ramos; V. Nacher; M. Navarro; A. Carretero; A. Sánchez-Chardi; L. Mendes-Jorge; A. Rodriguez-Baeza; J. Ruberte

doi:10.1016/j.exer.2015.03.019

Imaging of cellular aging in human retinal blood vessels

J. Catita, M. López-Luppo, D. Ramos, V. Nacher, M. Navarro, A. Carretero, A. Sánchez-Chardi, L. Mendes-Jorge, A. Rodriguez-Baeza, J. Ruberte

Research output: Contribution to journal › Review article › Research › peer-review

16 Citations (Scopus)

Abstract

© 2015 Elsevier Ltd. To date two main aging vascular lesions have been reported in elderly human retinas: acellular capillaries and microaneurysms. However, their exact mechanism of formation remains unclear. Using high resolution microscopy techniques we revise cellular alterations observed in aged human retinal vessels, such as lipofuscin accumulation, caveolae malfunction, blood basement membrane disruption and enhanced apoptosis that could trigger the development of these aging vascular lesions. Moreover, we have generated a set of original images comparing retinal vasculature between middle and old aged healthy humans to show in a comprehensive manner the main structural and ultrastructural alterations occurred during age in retinal blood vessels.

Original language	English
Pages (from-to)	14-25
Journal	Experimental Eye Research
Volume	135
DOIs	https://doi.org/10.1016/j.exer.2015.03.019
Publication status	Published - 1 Jun 2015

Keywords

Acellular capillaries
Aging
Cellular senescence
Lipofuscin accumulation
Microaneurysms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.exer.2015.03.019

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title = "Imaging of cellular aging in human retinal blood vessels",

abstract = "{\textcopyright} 2015 Elsevier Ltd. To date two main aging vascular lesions have been reported in elderly human retinas: acellular capillaries and microaneurysms. However, their exact mechanism of formation remains unclear. Using high resolution microscopy techniques we revise cellular alterations observed in aged human retinal vessels, such as lipofuscin accumulation, caveolae malfunction, blood basement membrane disruption and enhanced apoptosis that could trigger the development of these aging vascular lesions. Moreover, we have generated a set of original images comparing retinal vasculature between middle and old aged healthy humans to show in a comprehensive manner the main structural and ultrastructural alterations occurred during age in retinal blood vessels.",

keywords = "Acellular capillaries, Aging, Cellular senescence, Lipofuscin accumulation, Microaneurysms",

author = "J. Catita and M. L{\'o}pez-Luppo and D. Ramos and V. Nacher and M. Navarro and A. Carretero and A. S{\'a}nchez-Chardi and L. Mendes-Jorge and A. Rodriguez-Baeza and J. Ruberte",

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doi = "10.1016/j.exer.2015.03.019",

language = "English",

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TY - JOUR

T1 - Imaging of cellular aging in human retinal blood vessels

AU - Catita, J.

AU - López-Luppo, M.

AU - Ramos, D.

AU - Nacher, V.

AU - Navarro, M.

AU - Carretero, A.

AU - Sánchez-Chardi, A.

AU - Mendes-Jorge, L.

AU - Rodriguez-Baeza, A.

AU - Ruberte, J.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - © 2015 Elsevier Ltd. To date two main aging vascular lesions have been reported in elderly human retinas: acellular capillaries and microaneurysms. However, their exact mechanism of formation remains unclear. Using high resolution microscopy techniques we revise cellular alterations observed in aged human retinal vessels, such as lipofuscin accumulation, caveolae malfunction, blood basement membrane disruption and enhanced apoptosis that could trigger the development of these aging vascular lesions. Moreover, we have generated a set of original images comparing retinal vasculature between middle and old aged healthy humans to show in a comprehensive manner the main structural and ultrastructural alterations occurred during age in retinal blood vessels.

AB - © 2015 Elsevier Ltd. To date two main aging vascular lesions have been reported in elderly human retinas: acellular capillaries and microaneurysms. However, their exact mechanism of formation remains unclear. Using high resolution microscopy techniques we revise cellular alterations observed in aged human retinal vessels, such as lipofuscin accumulation, caveolae malfunction, blood basement membrane disruption and enhanced apoptosis that could trigger the development of these aging vascular lesions. Moreover, we have generated a set of original images comparing retinal vasculature between middle and old aged healthy humans to show in a comprehensive manner the main structural and ultrastructural alterations occurred during age in retinal blood vessels.

KW - Acellular capillaries

KW - Aging

KW - Cellular senescence

KW - Lipofuscin accumulation

KW - Microaneurysms

U2 - 10.1016/j.exer.2015.03.019

DO - 10.1016/j.exer.2015.03.019

M3 - Review article

VL - 135

SP - 14

EP - 25

ER -

Imaging of cellular aging in human retinal blood vessels

Abstract

Keywords

UN SDGs

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