IL-17A concentration of seminal plasma and follicular fluid in infertile men and women with various clinical diagnoses

Mohammada Sabbaghi, Raheleh Aram, Hessam Roustaei, Mahla Fadavi Islam, Maryam Daneshvar, A. Raúl Castaño, Alireza Haghparast*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)


Seminal plasma and follicular fluid (FF) cytokine analysis are valuable tools for diagnoses and validation of therapeutic approaches for improving the chance of conception. Despite the initial discovery over a decade ago, the IL-17 family has not received much attention in the case of infertility. In this study, we analyzed the level of IL-17A in seminal plasma, follicular fluid and blood serum of infertile patients with different clinical diagnoses by Enzyme Linked Immunosorbent Assay (ELISA). The results showed that the level of IL-17A was higher in seminal plasma and blood serum of varicocele patients than the control group. The level of this cytokine was higher in follicular fluid of endometriosis, polycystic ovary syndrome (PCOS) and tubal factor patients than the control group. A similar elevation in IL-17A level was observed in blood serum of these patients. Furthermore, there was a correlation between the numbers of meiosis I (MI) oocytes and the level of blood serum and follicular fluid IL-17A in PCOS patients. Our data suggest a putative role of IL-17A in mediating these conditions and may have possible applications in the development of more effective diagnostic tools and therapeutic treatments for human reproductive disorders. © 2014 Informa Healthcare USA, Inc.
Original languageEnglish
Pages (from-to)617-626
Number of pages10
JournalImmunological Investigations
Issue number7
Publication statusPublished - 1 Jan 2014


  • Blood
  • Enzyme Linked Immunosorbent Assay (ELISA)
  • Follicular fluid
  • Human IL-17A
  • Seminal plasma


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