The CD36 molecule plays a pivotal role in a variety of immunological and cellular processes, including pathogen recognition, inflammation and apoptosis. Herein, we demonstrate that this gene is duplicated in goats, with two copies (CD36 and CD36-like) that display highly divergent mRNA expression profiles. In this way, CD36 mRNA is mostly expressed in the adipose tissue and heart whilst CD36-like mRNA shows a high expression in the liver. We have also found evidence of the presence of two paralogous CD36 and CD36-like genes in the bovine genome, suggesting that CD36 duplication took place before goat-cattle radiation, i.e. at least 20 MYR ago. Finally, we have characterized the polymorphism of the coding regions of the goat CD36 and CD36-like genes. In doing so, we have identified one synonymous polymorphism at the CD36-like gene (c.390A>C) that displays a significant association (P=0.04) with milk somatic cell count, a parameter often used to diagnose mastitis in domestic ruminants. © 2012 Elsevier Ltd.
|Journal||Comparative Immunology, Microbiology and Infectious Diseases|
|Publication status||Published - 1 Jan 2013|
- CD36 gene
- Gene duplication
Zidi, A., Castelló, A., Jordana, J., Carrizosa, J., Urrutia, B., Serradilla, J. M., & Amills, M. (2013). Identification of two paralogous caprine CD36 genes that display highly divergent mRNA expression profiles. Comparative Immunology, Microbiology and Infectious Diseases, 36, 1-7. https://doi.org/10.1016/j.cimid.2012.08.003