Identification of two paralogous caprine CD36 genes that display highly divergent mRNA expression profiles

A. Zidi, A. Castelló, J. Jordana, J. Carrizosa, B. Urrutia, J. M. Serradilla, M. Amills

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1 Citation (Scopus)

Abstract

The CD36 molecule plays a pivotal role in a variety of immunological and cellular processes, including pathogen recognition, inflammation and apoptosis. Herein, we demonstrate that this gene is duplicated in goats, with two copies (CD36 and CD36-like) that display highly divergent mRNA expression profiles. In this way, CD36 mRNA is mostly expressed in the adipose tissue and heart whilst CD36-like mRNA shows a high expression in the liver. We have also found evidence of the presence of two paralogous CD36 and CD36-like genes in the bovine genome, suggesting that CD36 duplication took place before goat-cattle radiation, i.e. at least 20 MYR ago. Finally, we have characterized the polymorphism of the coding regions of the goat CD36 and CD36-like genes. In doing so, we have identified one synonymous polymorphism at the CD36-like gene (c.390A>C) that displays a significant association (P=0.04) with milk somatic cell count, a parameter often used to diagnose mastitis in domestic ruminants. © 2012 Elsevier Ltd.
Original languageEnglish
Pages (from-to)1-7
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume36
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • CD36 gene
  • Gene duplication
  • Goat

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