Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study

Sandra Pérez-Recio; Natàlia Pallarès; Maria D. Grijota-Camino; Adrián Sánchez-Montalvá; Laura Barcia; Silvia Campos-Gutiérrez; Virginia Pomar; Ramón Rabuñal-Rey; María Elvira Balcells; Denzil Gazel; Natalia Montiel; Diego Vicente; Ivana Goić-Barišić; Thomas Schön; Jakob Paues; Ivana Mareković; Juana Cacho-Calvo; Aleksandra Barac; Delia Goletti; Mercedes García-Gasalla; José María Barcala; María Teresa Tórtola Fernández; Luis Anibarro; Isabel Suárez-Toste; Esther Moga; María José Gude-González; Rodrigo Naves; Tekin Karsligil; Tania Martin-Peñaranda; Goran Stevanovic; Matilde Trigo; Verónica Rubio; Ilkay Karaoǧlan; Nazan Bayram; Fernando Alcaide; Cristian Tebé; Miguel Santin

doi:10.1128/Spectrum.00972-21

Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study

Sandra Pérez-Recio, Natàlia Pallarès, Maria D. Grijota-Camino, Adrián Sánchez-Montalvá, Laura Barcia, Silvia Campos-Gutiérrez, Virginia Pomar, Ramón Rabuñal-Rey, María Elvira Balcells, Denzil Gazel, Natalia Montiel, Diego Vicente, Ivana Goić-Barišić, Thomas Schön, Jakob Paues, Ivana Mareković, Juana Cacho-Calvo, Aleksandra Barac, Delia Goletti, Mercedes García-GasallaJosé María Barcala, María Teresa Tórtola Fernández, Luis Anibarro, Isabel Suárez-Toste, Esther Moga, María José Gude-González, Rodrigo Naves, Tekin Karsligil, Tania Martin-Peñaranda, Goran Stevanovic, Matilde Trigo, Verónica Rubio, Ilkay Karaoǧlan, Nazan Bayram, Fernando Alcaide, Cristian Tebé, Miguel Santin

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value.0.6 IU_ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2.TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of.0.6 IU_ml21 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2.TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB22TB1 difference of.0.6 IU_ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.

Original language	English
Journal	Microbiology spectrum
Volume	9
Issue number	3
DOIs	https://doi.org/10.1128/Spectrum.00972-21
Publication status	Published - 2021

Keywords

QuantiFERON-TB gold plus
Diagnosis
Latent tuberculosis infection
Tuberculosis-specific CD8 T cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/Spectrum.00972-21

https://ddd.uab.cat/record/264458

Cite this

Pérez-Recio, S., Pallarès, N., Grijota-Camino, M. D., Sánchez-Montalvá, A., Barcia, L., Campos-Gutiérrez, S., Pomar, V., Rabuñal-Rey, R., Balcells, M. E., Gazel, D., Montiel, N., Vicente, D., Goić-Barišić, I., Schön, T., Paues, J., Mareković, I., Cacho-Calvo, J., Barac, A., Goletti, D., ... Santin, M. (2021). Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study. Microbiology spectrum, 9(3). https://doi.org/10.1128/Spectrum.00972-21

@article{4926706e97074439a9e0e89cde54f3f6,

title = "Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study",

abstract = "We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value.0.6 IU_ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2.TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of.0.6 IU_ml21 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2.TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB22TB1 difference of.0.6 IU_ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.",

keywords = "QuantiFERON-TB gold plus, Diagnosis, Latent tuberculosis infection, Tuberculosis-specific CD8 T cells",

author = "Sandra P{\'e}rez-Recio and Nat{\`a}lia Pallar{\`e}s and Grijota-Camino, {Maria D.} and Adri{\'a}n S{\'a}nchez-Montalv{\'a} and Laura Barcia and Silvia Campos-Guti{\'e}rrez and Virginia Pomar and Ram{\'o}n Rabu{\~n}al-Rey and Balcells, {Mar{\'i}a Elvira} and Denzil Gazel and Natalia Montiel and Diego Vicente and Ivana Goi{\'c}-Bari{\v s}i{\'c} and Thomas Sch{\"o}n and Jakob Paues and Ivana Marekovi{\'c} and Juana Cacho-Calvo and Aleksandra Barac and Delia Goletti and Mercedes Garc{\'i}a-Gasalla and Barcala, {Jos{\'e} Mar{\'i}a} and {T{\'o}rtola Fern{\'a}ndez}, {Mar{\'i}a Teresa} and Luis Anibarro and Isabel Su{\'a}rez-Toste and Esther Moga and Gude-Gonz{\'a}lez, {Mar{\'i}a Jos{\'e}} and Rodrigo Naves and Tekin Karsligil and Tania Martin-Pe{\~n}aranda and Goran Stevanovic and Matilde Trigo and Ver{\'o}nica Rubio and Ilkay Karaoǧlan and Nazan Bayram and Fernando Alcaide and Cristian Teb{\'e} and Miguel Santin",

year = "2021",

doi = "10.1128/Spectrum.00972-21",

language = "English",

volume = "9",

number = "3",

}

Pérez-Recio, S, Pallarès, N, Grijota-Camino, MD, Sánchez-Montalvá, A, Barcia, L, Campos-Gutiérrez, S, Pomar, V, Rabuñal-Rey, R, Balcells, ME, Gazel, D, Montiel, N, Vicente, D, Goić-Barišić, I, Schön, T, Paues, J, Mareković, I, Cacho-Calvo, J, Barac, A, Goletti, D, García-Gasalla, M, Barcala, JM, Tórtola Fernández, MT, Anibarro, L, Suárez-Toste, I, Moga, E, Gude-González, MJ, Naves, R, Karsligil, T, Martin-Peñaranda, T, Stevanovic, G, Trigo, M, Rubio, V, Karaoǧlan, I, Bayram, N, Alcaide, F, Tebé, C & Santin, M 2021, 'Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study', Microbiology spectrum, vol. 9, no. 3. https://doi.org/10.1128/Spectrum.00972-21

TY - JOUR

T1 - Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study

AU - Pérez-Recio, Sandra

AU - Pallarès, Natàlia

AU - Grijota-Camino, Maria D.

AU - Sánchez-Montalvá, Adrián

AU - Barcia, Laura

AU - Campos-Gutiérrez, Silvia

AU - Pomar, Virginia

AU - Rabuñal-Rey, Ramón

AU - Balcells, María Elvira

AU - Gazel, Denzil

AU - Montiel, Natalia

AU - Vicente, Diego

AU - Goić-Barišić, Ivana

AU - Schön, Thomas

AU - Paues, Jakob

AU - Mareković, Ivana

AU - Cacho-Calvo, Juana

AU - Barac, Aleksandra

AU - Goletti, Delia

AU - García-Gasalla, Mercedes

AU - Barcala, José María

AU - Tórtola Fernández, María Teresa

AU - Anibarro, Luis

AU - Suárez-Toste, Isabel

AU - Moga, Esther

AU - Gude-González, María José

AU - Naves, Rodrigo

AU - Karsligil, Tekin

AU - Martin-Peñaranda, Tania

AU - Stevanovic, Goran

AU - Trigo, Matilde

AU - Rubio, Verónica

AU - Karaoǧlan, Ilkay

AU - Bayram, Nazan

AU - Alcaide, Fernando

AU - Tebé, Cristian

AU - Santin, Miguel

PY - 2021

Y1 - 2021

N2 - We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value.0.6 IU_ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2.TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of.0.6 IU_ml21 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2.TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB22TB1 difference of.0.6 IU_ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.

AB - We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value.0.6 IU_ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2.TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of.0.6 IU_ml21 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2.TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB22TB1 difference of.0.6 IU_ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.

KW - QuantiFERON-TB gold plus

KW - Diagnosis

KW - Latent tuberculosis infection

KW - Tuberculosis-specific CD8 T cells

U2 - 10.1128/Spectrum.00972-21

DO - 10.1128/Spectrum.00972-21

M3 - Article

C2 - 34756079

SN - 2165-0497

VL - 9

JO - Microbiology spectrum

JF - Microbiology spectrum

IS - 3

ER -

Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this