Identification of Group 1 Coronavirus Antigen in Multisystemic Granulomatous Lesions in Ferrets (Mustela putorius furo)

J. Martínez, M. Reinacher, D. Perpiñán, A. Ramis

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31 Citations (Scopus)

Abstract

Tissues from nine ferrets with granulomatous lesions similar to those seen in feline infectious peritonitis were examined histopathologically and immunohistochemically. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils. Other less commonly seen lesions were granulomatous necrotizing vasculitis and endogenous lipid pneumonia. FCV3-70 monoclonal antibody produced immunolabelling of group 1 coronavirus antigen in tissue samples from eight animals, the antigen being present in the cytoplasm of macrophages in the different types of granulomatous lesions. © 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)54-58
JournalJournal of Comparative Pathology
Volume138
DOIs
Publication statusPublished - 1 Jan 2008

Keywords

  • Mustela putorius furo
  • coronavirus
  • feline coronavirus
  • ferret
  • granuloma
  • viral infection

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