Identification of Group 1 Coronavirus Antigen in Multisystemic Granulomatous Lesions in Ferrets (Mustela putorius furo)

J. Martinez; A. Ramis; M. Reinacher; D. Perpiñan

doi:https://doi.org/10.1016/j.jcpa.2007.10.002

Identification of Group 1 Coronavirus Antigen in Multisystemic Granulomatous Lesions in Ferrets (Mustela putorius furo)

J. Martinez, A. Ramis, M. Reinacher, D. Perpiñan

Department of Animal Health and Anatomy

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Abstract

Tissues from nine ferrets with granulomatous lesions similar to those seen in feline infectious peritonitis were examined histopathologically and immunohistochemically. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils. Other less commonly seen lesions were granulomatous necrotizing vasculitis and endogenous lipid pneumonia. FCV3-70 monoclonal antibody produced immunolabelling of group 1 coronavirus antigen in tissue samples from eight animals, the antigen being present in the cytoplasm of macrophages in the different types of granulomatous lesions. © 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	54-58
Journal	Journal of Comparative Pathology
Volume	138
DOIs	https://doi.org/10.1016/j.jcpa.2007.10.002
Publication status	Published - 1 Jan 2008

Keywords

Mustela putorius furo
coronavirus
feline coronavirus
ferret
granuloma
viral infection

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https://doi.org/10.1016/j.jcpa.2007.10.002

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title = "Identification of Group 1 Coronavirus Antigen in Multisystemic Granulomatous Lesions in Ferrets (Mustela putorius furo)",

abstract = "Tissues from nine ferrets with granulomatous lesions similar to those seen in feline infectious peritonitis were examined histopathologically and immunohistochemically. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils. Other less commonly seen lesions were granulomatous necrotizing vasculitis and endogenous lipid pneumonia. FCV3-70 monoclonal antibody produced immunolabelling of group 1 coronavirus antigen in tissue samples from eight animals, the antigen being present in the cytoplasm of macrophages in the different types of granulomatous lesions. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

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author = "J. Martinez and A. Ramis and M. Reinacher and D. Perpi{\~n}an",

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T1 - Identification of Group 1 Coronavirus Antigen in Multisystemic Granulomatous Lesions in Ferrets (Mustela putorius furo)

AU - Martinez, J.

AU - Ramis, A.

AU - Reinacher, M.

AU - Perpiñan, D.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Tissues from nine ferrets with granulomatous lesions similar to those seen in feline infectious peritonitis were examined histopathologically and immunohistochemically. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils. Other less commonly seen lesions were granulomatous necrotizing vasculitis and endogenous lipid pneumonia. FCV3-70 monoclonal antibody produced immunolabelling of group 1 coronavirus antigen in tissue samples from eight animals, the antigen being present in the cytoplasm of macrophages in the different types of granulomatous lesions. © 2007 Elsevier Ltd. All rights reserved.

AB - Tissues from nine ferrets with granulomatous lesions similar to those seen in feline infectious peritonitis were examined histopathologically and immunohistochemically. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils. Other less commonly seen lesions were granulomatous necrotizing vasculitis and endogenous lipid pneumonia. FCV3-70 monoclonal antibody produced immunolabelling of group 1 coronavirus antigen in tissue samples from eight animals, the antigen being present in the cytoplasm of macrophages in the different types of granulomatous lesions. © 2007 Elsevier Ltd. All rights reserved.

KW - Mustela putorius furo

KW - coronavirus

KW - feline coronavirus

KW - ferret

KW - granuloma

KW - viral infection

U2 - https://doi.org/10.1016/j.jcpa.2007.10.002

DO - https://doi.org/10.1016/j.jcpa.2007.10.002

M3 - Article

SN - 0021-9975

VL - 138

SP - 54

EP - 58

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

ER -

Identification of Group 1 Coronavirus Antigen in Multisystemic Granulomatous Lesions in Ferrets (Mustela putorius furo)

Abstract

Keywords

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