Identification of c.483C>T polymorphism in the caprine Tyrosinase-related protein 1(TYRP1) gene

Bouabid Badaoui*, Arianna Manunza, Mariasilvia D'Andrea, Fabio Pilla, Juan Capote, Jordi Jordana, Ainhoa Ferrando, Amparo Martínez, Juan V. Delgado, Vincenzo Landi, Mariano Gómez, Agueda L. Pons Barro, Mabrouk El-Ouni, Oriol Vidal, Marcel Amills

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


Tyrosinase-related protein 1 (TYRP1) has been shown to play a fundamental role in pigmentation both in human and mouse. In this work, we aimed to characterize the variability of the caprine TYRP1 gene and investigate its segregation in a wide array of goat breeds. By partially sequencing the coding region of the TYRP1 gene in 18 individuals from eight different breeds, we were able to identify a synonymous nucleotide substitution at exon 3 (c.483C>T). An extensive survey of Iberian and Balearic (N=175), Italian (N=99), Swiss (N=54), Asian (N=14), Canarian (N=92) and North African (N=117) goats with different coat colours was carried out. We found that the C-allele has a different distribution in European vs African breeds, being almost fixed in the latter. Moreover, the C-allele showed an increased frequency in white coated breeds (Girgentana, Grigia Molisana, Blanca de Rasquera and Saanen) when compared with those displaying a dark pigmentation (Cilentana Nera, Azpi Gorri and Murciano-Granadina). This could be due to genetic drift, migration and other factors associated with the demographic history of breeds under analysis or to a genetic hitchhiking event (c.483C>T frequencies would be shaped by a neighbouring causal mutation differentially selected in white and black goats). More refined studies will be needed to distinguish between these two alternative explanations.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalItalian Journal of Animal Science
Issue number1
Publication statusPublished - 2012


  • Coat colour
  • Goat
  • Tyrosinase-related protein 1


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