Identification of a protective allele against Alzheimer disease in the APOE gene promoter

Kartrin Beyer; José I. Lao; Milagros Gómez; Nadal Riutort; Pilar Latorre; José L. Mate; Aurelio Ariza

doi:https://doi.org/10.1097/00001756-200208070-00011

Identification of a protective allele against Alzheimer disease in the APOE gene promoter

Kartrin Beyer, José I. Lao, Milagros Gómez, Nadal Riutort, Pilar Latorre, José L. Mate, Aurelio Ariza

Department of Morphological Sciences

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Alzheimer disease (AD) risk is significantly influenced by the APOE2 and APOE4 alleles. In turn, the -491AT and THI/E47cs polymorphisms alter APOE gene expression levels. To determine whether these two alleles exert any significant effect on AD development we have analysed the genotypes of the APOE promoter -491AT and Thl/E47cs polymorphisms in 163 AD patients and 155 controls divided into three age at onset/age dependent subgroups. Our study has detected a Thl/E47cs-Tallele accumulation in healthy individuals over 75 years of age, which suggests it plays a protective role against AD. The Thl/E47cs-Tallele may provide greater protection against AD than APOE2, although this awaits proof of Thl/E47cs-T allele overrepresentation in healthy individuals of other populations. © 2002 Lippincott Williams & Wilkins.

Original language	English
Pages (from-to)	1403-1405
Journal	NeuroReport
Volume	13
DOIs	https://doi.org/10.1097/00001756-200208070-00011
Publication status	Published - 7 Aug 2002

Keywords

APOE promoter region polymorphisms
Alzheimer disease
Apolipoprotein E
Protective allele

Access to Document

https://doi.org/10.1097/00001756-200208070-00011

Cite this

@article{4066d694fcb54078b2ae378a79d7d3b3,

title = "Identification of a protective allele against Alzheimer disease in the APOE gene promoter",

abstract = "Alzheimer disease (AD) risk is significantly influenced by the APOE2 and APOE4 alleles. In turn, the -491AT and THI/E47cs polymorphisms alter APOE gene expression levels. To determine whether these two alleles exert any significant effect on AD development we have analysed the genotypes of the APOE promoter -491AT and Thl/E47cs polymorphisms in 163 AD patients and 155 controls divided into three age at onset/age dependent subgroups. Our study has detected a Thl/E47cs-Tallele accumulation in healthy individuals over 75 years of age, which suggests it plays a protective role against AD. The Thl/E47cs-Tallele may provide greater protection against AD than APOE2, although this awaits proof of Thl/E47cs-T allele overrepresentation in healthy individuals of other populations. {\textcopyright} 2002 Lippincott Williams & Wilkins.",

keywords = "APOE promoter region polymorphisms, Alzheimer disease, Apolipoprotein E, Protective allele",

author = "Kartrin Beyer and Lao, {Jos{\'e} I.} and Milagros G{\'o}mez and Nadal Riutort and Pilar Latorre and Mate, {Jos{\'e} L.} and Aurelio Ariza",

year = "2002",

month = aug,

day = "7",

doi = "https://doi.org/10.1097/00001756-200208070-00011",

language = "English",

volume = "13",

pages = "1403--1405",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Identification of a protective allele against Alzheimer disease in the APOE gene promoter

AU - Beyer, Kartrin

AU - Lao, José I.

AU - Gómez, Milagros

AU - Riutort, Nadal

AU - Latorre, Pilar

AU - Mate, José L.

AU - Ariza, Aurelio

PY - 2002/8/7

Y1 - 2002/8/7

N2 - Alzheimer disease (AD) risk is significantly influenced by the APOE2 and APOE4 alleles. In turn, the -491AT and THI/E47cs polymorphisms alter APOE gene expression levels. To determine whether these two alleles exert any significant effect on AD development we have analysed the genotypes of the APOE promoter -491AT and Thl/E47cs polymorphisms in 163 AD patients and 155 controls divided into three age at onset/age dependent subgroups. Our study has detected a Thl/E47cs-Tallele accumulation in healthy individuals over 75 years of age, which suggests it plays a protective role against AD. The Thl/E47cs-Tallele may provide greater protection against AD than APOE2, although this awaits proof of Thl/E47cs-T allele overrepresentation in healthy individuals of other populations. © 2002 Lippincott Williams & Wilkins.

AB - Alzheimer disease (AD) risk is significantly influenced by the APOE2 and APOE4 alleles. In turn, the -491AT and THI/E47cs polymorphisms alter APOE gene expression levels. To determine whether these two alleles exert any significant effect on AD development we have analysed the genotypes of the APOE promoter -491AT and Thl/E47cs polymorphisms in 163 AD patients and 155 controls divided into three age at onset/age dependent subgroups. Our study has detected a Thl/E47cs-Tallele accumulation in healthy individuals over 75 years of age, which suggests it plays a protective role against AD. The Thl/E47cs-Tallele may provide greater protection against AD than APOE2, although this awaits proof of Thl/E47cs-T allele overrepresentation in healthy individuals of other populations. © 2002 Lippincott Williams & Wilkins.

KW - APOE promoter region polymorphisms

KW - Alzheimer disease

KW - Apolipoprotein E

KW - Protective allele

U2 - https://doi.org/10.1097/00001756-200208070-00011

DO - https://doi.org/10.1097/00001756-200208070-00011

M3 - Article

SN - 0959-4965

VL - 13

SP - 1403

EP - 1405

JO - NeuroReport

JF - NeuroReport

ER -

Identification of a protective allele against Alzheimer disease in the APOE gene promoter

Abstract

Keywords

Access to Document

Fingerprint

Cite this