Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: Structure determination of both ternary complexes and implications for drug design

Alexandra Cousido-Siah, Francesc X. Ruiz, André Mitschler, Sergio Porté, Ángel R. De Lera, María J. Martín, Sonia Manzanaro, Jesús A. De La Fuente, Felix Terwesten, Michael Betz, Gerhard Klebe, Jaume Farrés, Xavier Parés, Alberto Podjarny

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Biochemistry, Genetics and Molecular Biology