Identification of a novel myositis-associated antibody directed against cortactin

Moisés Labrador-Horrillo, Maria Angeles Martínez, Albert Selva-O'Callaghan, Ernesto Trallero-Araguás, Josep M. Grau-Junyent, Miquel Vilardell-Tarrés, Candido Juarez

Research output: Contribution to journalReview articleResearchpeer-review

32 Citations (Scopus)

Abstract

© 2014 Elsevier B.V. Objective: The aim of this study is to describe a novel myositis-associated autoantibody (anti-cortactin antibody) and assess related clinical and immunological manifestations and its clinical significance. Methods: Adult patients with myositis (dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and inclusion body myositis), as well as patients with other autoimmune diseases and non-inflammatory myopathies were analyzed for the presence of anti-cortactin antibody using in-house developed ELISA and immunoblotting techniques with a commercial source of purified cortactin. The cut-off for positive status was determined in a group of healthy volunteers. Results: Antibody against cortactin was positive in 7/34 (20%) polymyositis patients, 9/117 (7.6%) dermatomyositis, 2/7 (26%) immune-mediated necrotizing myopathy, and none of the 4 patients with inclusion body myositis. The antibody also tested positive in 3/101 patients with other autoimmune diseases (2 systemic sclerosis and 1 systemic lupus erythematosus), and in 1/29 patients with non-inflammatory myopathy. No relevant association with specific clinical features was found in patients with these antibodies. Anti-cortactin antibody was more frequently positive in patients with polymyositis and immune-mediated necrotizing myopathy than in the remaining myositis patients, and was the only myositis autoantibody found in sera of 3 patients from these groups. Conclusions: Our data indicate that cortactin is a novel target antigen in patients with autoimmune diseases, especially patients with polymyositis or immune-mediated necrotizing myopathy. Anti-cortactin can be considered a new myositis-associated antibody.
Original languageEnglish
Pages (from-to)1008-1012
JournalAutoimmunity Reviews
Volume13
Issue number10
DOIs
Publication statusPublished - 1 Oct 2014

Keywords

  • Anti-CTTN antibody
  • Cortactin
  • MAA
  • Myositis-associated autoantibody

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