Identification of a novel HLA-DRB1 allele, DRB1*0108, by sequence-based DRB typing in two siblings

M. Martinez-Gallo, L. Martinez-Lostao, M. A. Martinez-Carretero, I. Gago, P. Maroto, J. L. Rodriguez-Sanchez, O. De La Calle-Martin

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

We report here a novel DRB1 allele identified during sequence-based HLA-DRB typing. This allele was detected during routine HLA typing of a patient and his family prior to bone marrow transplantation. The new allele, DRB1*0108, was found in the patient and in a brother. Molecular cloning and sequencing confirmed that the new DRB1 allele is identical to DRB1*0101 at exon 2 except for a single nucleotide substitution at codon 37 (TCC→TAC), changing the encoded serine to tyrosine. This position of the β1 domain lies in the floor of the antigen-binding groove and shows the highest polymorphism among DRB1 alleles.

Original languageEnglish
Pages (from-to)350-351
Number of pages2
JournalTissue Antigens
Volume59
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Based typing
  • HLA-DRB1*01
  • Sequence

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