Identification and distribution of microglial cells in the cerebral cortex of the lizard: A histochemical study

Bernardo Castellano, Berta Gonzalez, Ishar Dalmau, Jose Miguel Vela

    Research output: Contribution to journalArticleResearchpeer-review

    26 Citations (Scopus)

    Abstract

    The histochemical demonstration of nucleoside diphosphatase as a specific microglial marker was used to study the distribution of this glial cell type in the cerebral cortex of Podarcis muralis and Podarcis hispanica. Our results showed that in both species, NDPase staining was specific for the microglial cell population and that microglial cells displayed a specific localization pattern in the different cortical areas. In the medial cortex, microglial cells were principally found in the outer and inner plexiform layers in the strata adjacent to the granular layer. Moreover, some microglial cells were found near the ependymal layer, but no microglial cells were normally present near the brain surface and never in the deep inner plexiform layer. In the dorsomedial cortex, microglial cells were found near the brain surface in the outer plexiform layer, in the upper part of the granular layer, and near the ependymal layer. No microglial cells were found, however, in the outer and inner plexiform layers adjacent to the granular layer. Finally, in the dorsolateral cortex, microglial cells were located in the upper part of the outer plexiform layer, in and bordering the granular layer, and scattered in the inner plexiform layer. This layered‐pattern distribution of microglial cell population in the cerebral cortex of the lizard differs from the apparently homogeneous distribution of microglia in the brain of mammals. Copyright © 1991 Wiley‐Liss, Inc.
    Original languageEnglish
    Pages (from-to)434-444
    JournalJournal of Comparative Neurology
    Volume311
    Issue number3
    DOIs
    Publication statusPublished - 1 Jan 1991

    Keywords

    • glial cells
    • histochemistry
    • microglial marker
    • nucleoside diphosphatase
    • reptiles

    Fingerprint Dive into the research topics of 'Identification and distribution of microglial cells in the cerebral cortex of the lizard: A histochemical study'. Together they form a unique fingerprint.

  • Cite this