Ibuprofen therapy resulted in significantly decreased tissue bacillary loads and increased survival in a new murine experimental model of active tuberculosis

Cristina Vilaplana, Elena Marzo, Gustavo Tapia, Jorge Diaz, Vanesa Garcia, Pere Joan Cardona

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107 Citations (Scopus)

Abstract

C3HeB/FeJ mice infected with Mycobacterium tuberculosis were used in an experimental animal model mimicking active tuberculosis in humans to evaluate the effect of antiinflammatory agents. No other treatment but ibuprofen was given, and it was administered when the animals' health started to deteriorate. Animals treated with ibuprofen had statistically significant decreases in the size and number of lung lesions, decreases in the bacillary load, and improvements in survival, compared with findings for untreated animals. Because antiinflammatory agents are already on the market, further clinical trials should be done to evaluate this effect in humans as soon as possible, to determine their suitability as coadjuvant tuberculosis treatment. © 2013 The Author 2013. All rights reserved.
Original languageEnglish
Pages (from-to)199-202
JournalJournal of Infectious Diseases
Volume208
Issue number2
DOIs
Publication statusPublished - 15 Jul 2013

Keywords

  • active tuberculosis
  • antiinflammatory agents
  • bacillary load
  • C3HeB/FeJ mice
  • ibuprofen
  • survival
  • tuberculosis
  • tuberculosis coadjuvant treatment
  • tuberculosis treatment

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