Hypovitaminosis D in type 2 diabetes: Relation with features of the metabolic syndrome and glycemic control

Inka Miñambres, Jose Luis Sánchez-Quesada, Irene Vinagre, Joan Sánchez-Hernández, Eulalia Urgell, Alberto De Leiva, Antonio Pérez

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)


© 2015 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted. Aim: To assess the association of hypovitaminosis D with clinical and biochemical characteristics of type 2 diabetic patients and to determine the effect of glycemic control optimization on 25-hydroxyvitamin D (25(OH)D) concentrations. Methods: Cross-sectional study of 63 patients with type 2 diabetes (mean age 60±9.8 years, 69.8% men). Twenty of the 63 patients were also studied before and after glycemic control optimization. Results: Mean 25(OH)D concentrations were 63.64±25.51nmol/L and 74.6% of patients had hypovitaminosis D. Compared with patients with vitamin D sufficiency, patients with hypovitaminosis D had higher prevalence of overweight or obesity (72.3% versus 37.5%; p=0.012) and higher VLDL cholesterol (VLDL-c) (0.71 (0.24-3.59) versus 0.45 (0.13-1.6) mmol/L; p=0.011) and C-reactive protein (3.28 (0.36-17.69) versus 1.87 (0.18-17.47) mg/L; p=0.033) concentrations. The composition of HDL particles also differed in both groups, with higher relative content of triglycerides and lower of cholesterol in patients with hypovitaminosis D. After adjustment for age, seasonality and BMI, differences remained significant for VLDL-c and triglyceride content of HDL. No differences were found regarding other diabetes characteristics. Improvement of glycemic control (HbA1c 9.4 (7.6-14.8) versus 7.3 (6.2-8.7)%; p=0.000) was accompanied by a decrease in 25(OH)D concentrations (72.7±33.3 to 59.0±21.0nmol/L; p=0.035). Correlation analysis revealed that changes in 25(OH)D concentrations were negatively associated to changes in HbA1c (r-0.482; p=0.032). Conclusion: Hypovitaminosis D is associated with features of the metabolic syndrome in type 2 diabetes and improvement of glycemic control decreases 25(OH)D concentrations.
Original languageEnglish
Pages (from-to)160-165
JournalEndocrine Research
Issue number3
Publication statusPublished - 1 Jan 2015


  • Atherogenic dyslipidemia
  • Glucose
  • Vitamin D


Dive into the research topics of 'Hypovitaminosis D in type 2 diabetes: Relation with features of the metabolic syndrome and glycemic control'. Together they form a unique fingerprint.

Cite this